Comments number

Docket 02D-0324 Drugs, Biologies and Medical Devices derived from bioengineered plants Comment Number EC-43 volume 9. 

Here s what those numbers and letters surrounded by the chasing-arrows symbol on the bottom of plastic bottles and other food storage containers mean. (If you can t find a number, call the manufacturer directly. On packaged food products, there is usually a toll-free question/comment number listed.) ... 

KRDPA I can make a couple of comments. Number one, it is generally the opinion that the conversion rate of SO2 to S0i in a plume is photochemical. The conversion rates even in a most liberal sense estimated to be anywhere from. 5 to 4 percent per hour. At night the conversion is almost zero. 

KRUPA I have a couple comments. Number one, you almost find an Identical situation with CO2. 

Comment. Number of operators ranges from 1 to whatever. Speaking of common mathematical operators the maximum number is 4 (definite integral (see Fig. 6.47), sum and others). However, if we consider that a plot in Mathcad (see Fig. 6.11) is represented by an operator the maximum number of operands is questionable. In case of a plot, we can tell about variable number of operands too. 

Comment. Number of defaults of 3-D plots (additional tools of formatting) is a dozen higher than that of 2-D plots. 

We will almost always treat the case of a dilute gas, and almost always consider the approximation that the gas particles obey classical, Flarniltonian mechanics. The effects of quantirm properties and/or of higher densities will be briefly commented upon. A number of books have been devoted to the kinetic theory of gases. Flere we note that some... 

The values due to the two separate calculations are of the same quality we usually get from (pure) two-state calculations, that is, veiy close to 1.0 but two comments have to be made in this respect (1) The quality of the numbers are different in the two calculations The reason might be connected with the fact that in the second case the circle surrounds an area about three times larger than in the first case. This fact seems to indicate that the deviations are due noise caused by CIs belonging to neighbor states [e.g., the (1,2) and the (4,5) CIs]. (2) We would like to remind the reader that the diagonal element in case of the two-state system was only (—)0.39 [73] [instead of (—)1.0] so that incorporating the third state led, indeed, to a significant improvement. 

The number of C H2n+2 iso mers has been calculated for values of n from 1 to 400 and the comment made that the number of isomers of C167H336 exceeds the number of particles in the known universe (10 °) These obser vations and the historical background of isomer calcu lation are described in a pa per in the April 1989 issue of the Journal of Chemical Edu cat/on (pp 278-281)... 

Process type and comments Paper number in reference 88... 

Compound CAS Registry Number Mp, °C Solubihty, 25°C, g/100 g water Comments... 

Compound CAS Registry Number AppHcation and function Comments Reference... 

Ingredient Chemical identity CAS Registry Number Comment... 

The nomenclature of penicillins requires special comment. Compound (2) can be named as follows (a) penicillin G (b) benzylpenicillin (note that the term penicillin may refer to the compound class (1), to the structural fragment (3) or, especially in the medical literature, to compound (2) itself) (c) 6/3-phenylacetamidopenicillanic acid (d) 2,2-dimethyl-6/3-phenylacetamidopenam-3a -carboxylic acid (e) (2S,5i ,6i )-3,3-di-methyl-7-oxo-6-(2-phenylacetamido)-4-thia-l-azabicyclo[3.2.0]heptane-2-carboxylic acid and (f) [2S-(2a,5a,6/3)]-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-l-azabicyclo-[3.2.0]heptane-2-carboxylic acid. The numbered system shown in (2) is the one most commonly used in the penicillin literature and will be used in this chapter note that different number is used when (2) is named according to (e) and (f) above. 

Edgren carried out a number of studies in which bioassays were used to compare the widely differing potencies of a number of analogues of 17/i-oestradiol that were modified in the 18-position. Commenting on the use of potency ratios, Edgren concluded that they were only valid for specific substances and test systems and useless for product safety testing . These problems could have important consequences for any attempt to establish the potency of specific environmental EDs or environmentally relevant mixtures. 

Briefly describe the processing route which you would specify for making the pressure hull of Problem 27.2 from each of the materials listed in the table. Comment on any particular problems which might be encountered. [You may assume that the detailed design will call for a number of apertures in the wall of the pressure hull.]... 

It has already been pointed out that crystalline non-polar polymers do not normally have solvents well below their crystalline melting point and the same comment can apply to a large number of polar crystalline polymers. 

What-if produces a table of narrative questions and answers suggesting accident scenano.s. consequences, and mitigation. Table 3.3.2-1 shows a typical What-If analysis for the Dock 8. < in the left in the line above the table is indicated the line/vessel that is being analyzed. To the right is the date and page numbers. The first row in the table contains the column headings beginning with i ie what-if question followed by the consequences, safety levels, scenario number and comments. 11C comments column may contain additional descriptive information or actions/ recommendations. 

Type Projected UsebI Life (Years) Projected Cycb Lite (Number of Cycles) Wet Shelf life (Months) Comments ... 

A final comment on the interpretation of stochastic simulations We are so accustomed to writing continuous functions—differential and integrated rate equations, commonly called deterministic rate equations—that our first impulse on viewing these stochastic calculations is to interpret them as approximations to the familiar continuous functions. However, we have got this the wrong way around. On a molecular level, events are discrete, not continuous. The continuous functions work so well for us only because we do experiments on veiy large numbers of molecules (typically 10 -10 ). If we could experiment with very much smaller numbers of molecules, we would find that it is the continuous functions that are approximations to the stochastic results. Gillespie has developed the stochastic theory of chemical kinetics without dependence on the deterministic rate equations. 

Comment When using data for LOELs, LOAELs, NOELs, or NOAELs, it is important to be aware of their limitations. As discussed in the chapter, statistical uncertainty exists in the determination of these parameters due to the limited number of animals used in the studies to determine the values. However, any toxic effect might be used for the NOAEL and LOAEL so long as it is the most sensitive toxic effect and considered like it to occur in humans. 

Taken from W. S. Fyfe, Geochemistry, Oxford University Press, 1974, with some modifications and additions to incorporate later data. The detailed numbers are subject to various assumptions in the models of the global distribution of the various rock types within the crust, but they are broadly acceptable as an indication of elemental abundances. See also Table 1 in C. K. J0RGENSEN, Comments Astrophys. 17, 49-101 (1993). 

The number of problems that can be solved exactly in mechanics is not large. Once we have to treat three interacting bodies, life becomes very difficult indeed. This comment applies to classical mechanics just as to quantum mechanics. What we often do is to look for a simple, idealized problem that we can solve exactly, and then treat the real problem in hand as some kind of perturbation on the idealized one. 

Tliis is one of the most actively developing and closely watched fields of heterocyclic tautomerism—only the study of purines and pyrimidines is of comparable contemporary interest. Tire number of references is so high that many relevant works have had to be neglected, whereas in other sections of this chapter relatively minor contributions have been commented on because they pertained to a field where few contributions are available. Tire selection criteria were (1) all pertinent authors are quoted at least once, (2) full papers are preferred to communications or letters, and (3) recent works are preferred to earlier ones because they usually quote the previous publications. 

If some fields may be empty in the sublevels, all the fields in the main level are required for each entry. A new chiral separation record can be added in CHIRBASE solely if the authors correctly identify both sample and CSP. Since the beginning of the project, our policy has been to contact the authors of all publications containing incomplete, ambiguous or inconsistent data and to ask for additional information. Providing the separations with unique case numbers helps us considerably in this essential task, and also facilitates avoiding redundancies in the database. When chiral separations are reported for the second time in a new publication with exactly the same chromatographic conditions, this is stated in a footnote added in the field comments . In this field, miscellaneous information that cannot appear elsewhere are listed (detection limit, description of a reported chromatogram, racemization study, mobile phase limitations, etc.). 

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