Broadly acceptable

Nuclear power plants of the future are to be designed and operated with the objective of better fiilfiUing the role as a bulk power producer that, because of reduced vulnerabiUty to severe accidents, should be more broadly accepted and implemented. Use of these plants could help stem the tide of environmental damage caused by air pollution from fossil-fuel combustion products (64). 

Since 1970 tlie field of healtli risk assessment Itas received widespread attention witliin both tlie scientific and regulatoiy committees. It has also attracted tlie attention of the public. Properly conducted risk assessments have received fairly broad acceptance, in part because they put into perspective the terms to. ic, Itazard, and risk. Toxicity is an inlierent property of all substances. It states tliat all chemical and physical agents can produce adverse healtli effects at some dose or under specific exposure conditions. In contrast, exposure to a chemical tliat lias tlie capacity to produce a particular type of adverse effect, represents a health hazard. Risk, however, is tlie probability or likelihood tliat an adverse outcome will occur in a person or a group tliat is exposed to a particular concentration or dose of the hazardous agent. Tlierefore, risk can be generally a function of exposure and dose. Consequently, healtli risk assessment is defined as tlie process or procedure used to estimate tlie likelihood that... 

Taken from W. S. Fyfe, Geochemistry, Oxford University Press, 1974, with some modifications and additions to incorporate later data. The detailed numbers are subject to various assumptions in the models of the global distribution of the various rock types within the crust, but they are broadly acceptable as an indication of elemental abundances. See also Table 1 in C. K. J0RGENSEN, Comments Astrophys. 17, 49-101 (1993). 

The Handbook of Environmental Chemistry is available both in print and online via www.springerlink.com/content/110354/. Articles are published online as soon as they have been approved for publication. Authors, Volume Editors and Editors-in-Chief are rewarded by the broad acceptance of The Handbook of Environmental Chemistry by the scientific community, from whom suggestions for new topics to the Editors-in-Chief are always very welcome. 

A number of approaches have been made to justifying the implementation of IT systems within drug discovery, and ELN is no exception, although these systems do seem to have generated something of their own mythology in terms of return-on-investment ( ROl ) and other justification methods. What is clear from our work with major pharmaceutical customers is that there is broad acceptance of the benefits to be accrued from implementation of an ELN. The areas of benefit at which the majority of customers have looked are ... 

Although open tubular columns have been used for RPLC,42 most applications use packed columns. The most widely used column packings are formed by chemically bonding butyl (C4), octyl (C8), or octadecyl (C18) chains to a silica surface. Phenyl (Ph), cyano (CN), and amino (NH2) functionalities are also used. Polymeric packings which are finding broad acceptance include alkyl-grafted poly(methylmethacrylate) and alkyl-grafted or unmodified... 

Although Europe is at the forefront in many fields, a lack of co-ordination and of well defined targets could make it less suited to commercial and industrial exploitation. But at present there are some efforts to fund and develop a scientifically sound and broadly accepted European roadmap. 

Blaedel et al. (1951), Wilson (1952) and Laitinen (1960) have put forward more broadly accepted and recommended criteria of rejecting an observation. 

The LC/MS combination has been practiced for many years. Various types of interfaces have been developed for LC/MS, including the fast atom bombardment (FAB) source by Barber et al. in 1981 and thermospray by Blakely and VestaL in 1983. However, a broad acceptance of... 

In addition to catalytically active transition metal complexes, several stable, electrophilic carbene complexes have been prepared, which can be used to cyclopropanate alkenes (Figure 3.32). These complexes have to be used in stoichiometric quantities to achieve complete conversion of the substrate. Not surprisingly, this type of carbene complex has not attained such broad acceptance by organic chemists as have catalytic cyclopropanations. However, for certain applications the use of stoichiometric amounts of a transition metal carbene complex offers practical advantages such as mild reaction conditions or safer handling. 

A broadly accepted definition of process analytics is difficult to capture as the scope of the methodology has increased significantly over the course of its development. What was once a subcategory of analytical chemistry or measurement science has developed into a much broader system for process understanding and control. Historically, a general definition of process analytics could have been ... 

The selection of variables is of central importance for the outcome of a system comparison on environmental and resource use impacts. The ideal variable or set of variables respectively provides information and describes the state of environmental phenomena with certain significance. Thus, applying a set of variables should make it possible to monitor and assess the state of the environment, to identify changes and trends, to transmit scientific data to become relevant for policy, and to evaluate already implemented policy measures. The concept of environmental indicators is broadly accepted as an adequate tool. Accordingly, an indicator is defined as a parameter or a value derived from parameters, which indicates the state of the environment with significance extending beyond that which is directly associated with a parameter value. A parameter s definition in this context is a property that is measured or observed (OECD 1994). Fieri et al. (1996) states that the purposes of indicators are as follows ... 

To evaluate the safety aspects of a drug intended for use in food-producing animals, multistep procedures have to be applied. A major portion of these procedures refer to toxicity studies. Over the last 30 years, a broadly accepted package... 

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