Collagen Wound Dressings

The skin works as a barrier to the external environment, which is responsible for protecting the organism from water loss and penetration of harmful substances. If this 

As a natural constituent of connective tissue and major structural protein, collagen is implicated in all phases of the wound healing process (hemostasis, inflammation, migration, proliferation and maturation) and controls the cellular functions such as cell shape and differentiation, migration, and synthesis of a number of proteins [100]. The use of collagen dressings may seem attractive in view of their functions to  

Collagen can be used in acute wounds—where damage of the tissue is usually completely healed within 8-12 weeks and this type of wound leaves a bit of a scar [102] —like burns [103] and medical surgery wounds, or in chronic wounds—which are hard to heal, may recur and the healing duration is more than 12 weeks—like ulcers [ 104] and tumors. 

1 Modifications in Collagen Structure for Wound Dressings Applications 

A downside of the chemical stabilization techniques is the formation of undesirable potentially toxic residues in the collagen-based biomaterial. 

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Bruck, S.D. 1991. Biostabdity of materials and implants. J. Long-Term Effects Med. Implants 1 89-106. Ceravolo, F. and Li, S.T. 1988. Alveolar ridge augmentation utilizing collagen wound dressing. Int. J. Oral... 

F. Ceravolo and S. T. Li, Int. J. of Oral Implant., 4, 15-18 (1988). "Alveolar Ridge Augmentation Utilizing Collagen Wound Dressing."... 

Collagen Collagen wound dressings are available in the form of gels, pads, particles, pastes, powders, sheets or solutions derived from bovine, porcine or avian sources BIOPAD Angetini Pharma, Inc Type I Collagen... 

The in vitro biocompatibihty of wound dressings in regards to fibroblasts has been assessed and compared with three commercial wound dressings made of collagen, alginate and gelatin. Methylpyrrolidinone chitosan and collagen were found to be the most compatible materials [305,306],... 

Chitosan has been associated with other biopolymers and with synthetic polymer dispersions to produce wound dressings. Biosynthetic wound dressings composed of a spongy sheet of chitosan and collagen, laminated with a gentamicyn sulphate-impregnated polyurethane membrane, have been produced and clinically tested with good results. 

Collagen/synthetic polymer Vascular repair skin repair wound dressings... 

Collagen s promotion of wound healing has also been reported for many years. Collagen protein is a natural biopolymer that In isolated and purified form is extraordinarily suitable for biomedical applications. The physical, physicochemical, and biological properties of collagen make it an interesting component for so-called active wound dressings. 

M. Chvapil and J. Owen, Reaction of various skin wounds in the rat to collagen sponge dressing. J. Surg. Res. 41 410 (1986). 

F. H. Collagen-based wound dressings—control of the pore structure and morphology. J. Biomed. Mater. Res. 1986, 20, 1219-1228. 

Collagen, being a major protein of connective tissues in animals, is widely distributed in skin, bones, teeth, tendons, eyes, and most other tissues in the body and accounts for about one-third of the total protein content in mammals. It also plays an important role in the formation of tissues and organs and is involved in various cells in terms of their functional expression. Collagen as a biomaterial has been used for repair and reconstruction of tissues and as an agent for wound dressing. 

Temporary replacement skins have also been studied by using velour fabrics (usually a nylon or Dacron) backed by a polymeric film (silicone or protein) (36). synthetic polypeptides (37). collagen (38). and dextran hydrogels (39). These replacement materials are only for short term use and could be classed as wound dressings. Although they do prevent gross infection and body fluid loss, they do not duplicate any of the other functions of the skin. A true artificial skin does not yet exist. 

Chen, J.P., Chang, G.Y., Chen, J.K., 2008a. Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloids and Surfaces a-Physicochemical and Engineering Aspects 313, 183-188. 

Research and Development Collagen based wound dressings [Armstrong et al., 1986]... 

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