Chronic wounds

Miyasaki KT, Wilson ME, Brunetti AJ, Genco RJ (1986) Oxidative and nonoxidative killing of actinobacillus actinomycetemcomitans by human neutrophils. Infect Immun 53(1) 154—160 Moore K (1999) CeU biology of chronic wounds the role of inflammation. J Wound Care 8(7) 345-348 Moses MA (1997) The regulation of neovascularization of matrix metaUoproteinases and their inhibitors. Stem Cells 15(3) 180-189... 

A pressure sore is a chronic wound that results from continuous pressure on the tissue overlying a bony prominence. This pressure impedes blood flow to the dermis and subcutaneous fat, resulting in tissue damage and necrosis.37,38... 

Wounds can be categorized as acute (healing quickly on their own) or chronic (healing slowly, and often requiring medication). Chronic wounds, such as ulcers (Table 10.9), occur if some influence disrupts the normal healing process. Such influences can include diabetes, malnutrition, rheumatoid arthritis and ischaemia (inadequate flow of blood to any part of the body). Elderly people are particularly susceptible to developing chronic wounds, often resulting in the necessity for hospitalization. Ulceration (particularly of the limbs or extremities) associated with old age,... 

Plotner AN, Mostow EN. (2010) A review of bioactive materials and chronic wounds. Cutis 85 259-266. 

Wounds can be categorized as acute (healing quickly on their own) or chronic (healing slowly, and often requiring medication). Chronic wounds, such as ulcers (Table 7.3), occur if some... 

Chronic ulcers are a significant health problem in young and elderly individuals that culminates in disability, decreased productivity, and loss of independence [1, 2], The economic costs associated with chronic wounds are enormous for the healthcare system as well as for patients [3], The healing process is slow and often incomplete and patients not responding to conservative therapy become candidates for amputation [4],... 

Inflamed tissue associated with an oxidative stress as a consequence of a disbalance in the pro-oxidant/antioxidant homeostasis in chronic wounds is thought to drive a deleterious sequence of events that finally results in the non-healing state [29]. Experimental studies showed that wounds of delayed healing type are accompanied... 

Delayed re-epithelialisation and persistent epithelial defects are typical features of chronic ulcers which hardly heal [31, 37], It has been proposed that excessive and uncontrolled proteolytic activity is an important pathogenesis factor for chronic wounds [44]. Proteolysis is caused mainly by the oxidative stress accompanying an... 

The increase in levels of tissue CAT is compatible with previous results which showed that LLLT induced an increase in CAT activity of irradiated isolated cardio-myocytes compared to controls. It was suggested that laser therapy efficacy in chronic wounds and ulcers can be attributed to the activation of CAT in tissue fluids [62]. He-Ne laser has been shown to cause photoactivation and structural modifications of catalase enzymes that positively correlated with its functional properties in cell free system [63]. 

Lauer G, SoUberg S, Cole M, Flamme I, Sturzebecher J, Mann K, Kiieg T, Eming S (2000) Expression and proteolysis of vascular endothelial growth factor is increased in chronic wounds. J Invest Dermatol 115 12-18... 

Tarnuzzer RW, Schultz GS (1996) Biochemical analysis of acute and chronic wound environment. Wound Rep Reg 4 321-325... 

Similar to their modulation of angiogenesis, wound-site macrophages exhibit both pro- and antifibrotic functions required for acute and chronic wound stasis and remodeling.77 Profibrotic functions include the ability of macrophages to produce extracellular matrix (ECM) components such as fibronectin, thrombospondins, and... 

Schoenfelder U, Abel M, Wiegand C, Klemm D, Eisner P, Hipler U-C (2005) Biomaterials 26 6664 Influence of selected wound dressings on PMN elastase in chronic wound fluid and their antioxidative potential in vitro... 

Using online satellite maps of air pollution, I went looking for the cleanest places on Earth for a new place to live. It would have to be New Zealand, South America, South Africa or Thailand. I still remembered my experience with the chronic head wound and I therefore decided in August 2005 to move to Thailand with the same woman I visited Canada with, who also had an increasingly severe case of MCS. After a month in Thailand the chronic wound had healed again and I decided to stay there to live. Today, about a year and a half later, you can only see a scar where the wound once was and my eczema has disappeared. I alternate between living in the city or in countryside in the far... 

A new product, a combination of HA with iodine, Hyiodine , is effective in the healing of severe chronic wounds, as found in the extremities of diabetic patients [159]. 

Finally, the reputation of folkloristic medicine has been rehabilitated it has been shown that the pure alkaloids catharanthine (172), leurosine (183), loch-nerine, tetrahydroalstonine, vindoline (171), and vindolinine show some activity in lowering blood sugar. This fact has been established in fasted rats. In the case of skin cancers the magicians really might have cleaned and healed chronic wounds . 

High molecular size HA preparations, applied topically, promote healing of fresh skin wounds [156]. They also promote the healing of venous leg ulcers [157] and are useful in the management of chronic wounds [158]. 

Mast B, Schultz G (1996). Interactions of cytokines, growth factors, and proteases in acute and chronic wounds. Wound Rep. Reg. 4 411-420. 

Cullen B. The role of oxidized regenerated ceUulose/collagen in chronic wound repair. Part 2. Ostomy Wound Manage 2002 48(6 Suppl.) 8-13. Review. 

Chronic Wounds and Inflammation of the Skin and Oral Cavity. 44... 

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