Collagen dressings

As a natural constituent of connective tissue and major structural protein, collagen is implicated in all phases of the wound healing process (hemostasis, inflammation, migration, proliferation and maturation) and controls the cellular functions such as cell shape and differentiation, migration, and synthesis of a number of proteins [100]. The use of collagen dressings may seem attractive in view of their functions to ... 

The in vitro biocompatibihty of wound dressings in regards to fibroblasts has been assessed and compared with three commercial wound dressings made of collagen, alginate and gelatin. Methylpyrrolidinone chitosan and collagen were found to be the most compatible materials [305,306],... 

Chitosan has been associated with other biopolymers and with synthetic polymer dispersions to produce wound dressings. Biosynthetic wound dressings composed of a spongy sheet of chitosan and collagen, laminated with a gentamicyn sulphate-impregnated polyurethane membrane, have been produced and clinically tested with good results. 

Collagen/synthetic polymer Vascular repair skin repair wound dressings... 

Collagen s promotion of wound healing has also been reported for many years. Collagen protein is a natural biopolymer that In isolated and purified form is extraordinarily suitable for biomedical applications. The physical, physicochemical, and biological properties of collagen make it an interesting component for so-called active wound dressings. 

M. Chvapil and J. Owen, Reaction of various skin wounds in the rat to collagen sponge dressing. J. Surg. Res. 41 410 (1986). 

F. H. Collagen-based wound dressings—control of the pore structure and morphology. J. Biomed. Mater. Res. 1986, 20, 1219-1228. 

Collagen, being a major protein of connective tissues in animals, is widely distributed in skin, bones, teeth, tendons, eyes, and most other tissues in the body and accounts for about one-third of the total protein content in mammals. It also plays an important role in the formation of tissues and organs and is involved in various cells in terms of their functional expression. Collagen as a biomaterial has been used for repair and reconstruction of tissues and as an agent for wound dressing. 

Temporary replacement skins have also been studied by using velour fabrics (usually a nylon or Dacron) backed by a polymeric film (silicone or protein) (36). synthetic polypeptides (37). collagen (38). and dextran hydrogels (39). These replacement materials are only for short term use and could be classed as wound dressings. Although they do prevent gross infection and body fluid loss, they do not duplicate any of the other functions of the skin. A true artificial skin does not yet exist. 

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