Acute wounds

The fluid exuded from a fresh or acute wound generally exhibits high levels of various growth factors (as determined by bioassay or immunoassay analysis). In contrast, the concentration of... 

Human skin specimens were obtained from reduction abdominoplasty (tummy tuck) and used to generate acute wounds as described elsewhere [42]. A 3 mm biopsy punch was used to create an acute wound. Skin specimens were maintained at the air-liquid interface at 37°C, 5% CO2, and 95% relative humidity for 6-7 days. 

Significantly, the implanted biomaterial provokes a spectrum of macrophage differentiation and activation profiles locally at the site, depending on this broad cell type heterogeneity, tissue site physiology, and device properties. It is also likely that local activation and acute wound healing at the implant site provide chemotactic cues that recruit other monocytes and immature MPS cells to the implant site. 

Kainulainen V, Wang H, Schick C, Bernfield M. Syndecans, heparan sulfate proteoglycans, maintain the proteolytic balance of acute wound fluids. J Biol Chem 1998 273 11563-11569. 

W7. Wysocki, A. B., Kusakabe, A. O., Chang, S., and Tuan, T. L., Temporal expression of urokinase plasminogen activator, plasminogen activator inhibitor, and gelatinase-B in chronic wound fluid switches from a chronic to acute wound profile with progression to healing. Wound Repair Regen. 7, 154—165 (1999). 

Kaltostat (calcium/sodium alginate fibres in non-woven pads, ConvaTec) is used for moderafely to highly exuding chronic and acute wounds and for wounds with minor bleeding. 

Wounds can be classified into acute wounds and chronic wounds. While acute wounds take only a few weeks to heal, chronic wounds require several months to heal completely. Chronic wounds include venous leg ulcers and pressure sores. Wounds are not usually sterile. A wound may bear a level of 100,000 microorganisms per gram of tissue. Beyond this number, the wound may become infected. In some wounds the pathogens may be able to colonise (critical colonisation) and this is considered to be detrimental for wound healing. Wound bacteria can be acquired from the patient s own endogenous flora or from exogenous microbial contamination... 

Sikka, N. et al.. The use of mobile phones for acute wound care Attitudes and opinions of emergency department patients, / Health Commun 17(Suppl l) 37-42, 2012. 

Hart, J., 2002. Inflammation 1 its role in the heating of acute wounds. J. Wound Care... 

Collagen can be used in acute wounds—where damage of the tissue is usually completely healed within 8-12 weeks and this type of wound leaves a bit of a scar [102] —like burns [103] and medical surgery wounds, or in chronic wounds—which are hard to heal, may recur and the healing duration is more than 12 weeks—like ulcers [ 104] and tumors. 

Products with a low silver content These products are sufficient for low-grade infections in chronic wounds, but are more appropriately used as a barrier to infection in acute wounds, bums, and surgical injuries. 

Wounds can be subdivided into three broad categories. These are acute wounds, burns, and chronic wounds. Acute wounds are caused by trauma or surgery and usually require limited local care. Bums are classed into three subcategories based upon the extent of skin damage third degree bums are the most extreme with fiill thickness destruction of the skin. Chronic wounds require longer than usual to heal as a result of poor health, local pressure, diabetes, carcinoma, poor circulation, poor nutritional state, immunodeficiencies, infection, or advanced age. 

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