Polypeptide, synthetic

Chemical Class Fusion inhibitor, HIV polypeptide, synthetic I Clinical Pharmacology ... 

CSP. CMPA proteins, polypeptides Synthetic Polymers based on analytical and/or bead material... 

Rydon, Norman (p. 243, Plate 36) born in 1912 studied chemistry at London (B.Sc. 1931, Ph.D. 1933, D.Sc. 1938), D. Phil., Oxford 1939. Chemical Defence Experimental Section, 1940-1945. From 1945-1947 Member of Scientific Staff of the Lister Institute, then Reader at Birkbeck College, London, until 1949 and from 1949-1952 Reader at Imperial College, London. Professor at Manchester College of Science and Technology 1952-1957, Professor and Head of Department, Exeter University 1957-1977. Rydon s work outside of peptide research was on natural substances peptide topics at Exeter included cysteine peptides, sequential polypeptides, synthetic studies of ferredoxins. Chlorination followed by starchh-potassium iodide for the detection of peptides is known as Rydon-Smith reagent. 

A polymer is a macromolecule that is constructed by chemically linking together a sequent of molecular fragments. In simple synthetic polymers such as polyethylene or polystyrer all of the molecular fragments comprise the same basic unit (or monomer). Other poly me contain mixtures of monomers. Proteins, for example, are polypeptide chains in which eac unit is one of the twenty amino acids. Cross-linking between different chains gives rise to j-further variations in the constitution and structure of a polymer. All of these features me affect the overall properties of the molecule, sometimes in a dramatic way. Moreover, or... 

Polymer Solutions. Perhaps the most extensively studied macromolecular Hquid crystals are the synthetic polypeptides, such as poly( y-benzyl L-glutamate) [25513-40-0] (PBLG). PBLG is a homopolymer of the L-enantiomorph of a single amino acid with the foUowiag repeat unit. 

Biomechanical Machines. The mechanical properties of fibrous polypeptides could be put to use for the commercial production of fibers (qv) that are more elastic and resiUent than available synthetics (see Silk). The biochemical properties of proteins could also be harnessed for the conversion of mechanical energy to chemical energy (35). 

Some of these compounds could be considered as dietary additives, but various other terms, including pesticides, can also be used. They can have beneficial effects on the environment and this aspect will be discussed later. The ionophore monensin, which is an alicyclic polyether (Figure 1), is a secondary metabolite of Streptomyces and aids the prevention of coccidiosis in poultry. Monensin is used as a growth promoter in cattle and also to decrease methane production, but it is toxic to equine animals. " Its ability to act as an ionophore is dependent on its cyclic chelating effect on metal ions. ° The hormones bovine somatotropin (BST) and porcine somatotropin (PST), both of which are polypeptides, occur naturally in lactating cattle and pigs, respectively, but can also be produced synthetically using recombinant DNA methods and administered to such animals in order to increase milk yields and lean meat production. "... 

Synthetic experiments have established the constitution of the polypeptide and the succession of the amino-acids, proline being always at the distal end and the second amino-acid in the middle. 

Teramoto, A. and Fujita, H. Conformation-dependet Properties of Synthetic Polypeptides in the Helix-Coil Transition Region. Vol. 18, pp. 65— 149. 

The detection of the collagen-like threefold symmetric polypeptides, polyglycine4 and polyproline5, was the first help to elucidate the collagen structure using a synthetic peptide model. 

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