Molecular signatures

It has taken time for methods to be developed that meet the desire of microbial ecologists to learn more about carbon flow and microbial communities in natural environments. In recent years techniques have developed at considerable speed that offer the potential to answer some of the commonly asked questions. Use of C techniques for measuring carbon flow is one example. While questions still remain about the interpretation and relevance of some modern methods regarding the real makeup and interactions in mixed populations, there is no doubt that the use of biochemical or molecular signatures provides the best opportunity to advance our knowledge in this area. 

Shanmukh, S. Jones, L. Driskell, J. Zhao, Y. P. Dluhy, R. Tripp, R. A., Rapid and sensitive detection of respiratory virus molecular signatures using a silver nanorod array SERS sub strate, Nano Lett. 2006, 6, 2630 2636... 

Also identified during the mid-1990s was the APC (anaphase promoting complex - also known as the cyclosome), another multi-subunit cullin-containing E3 that mediates ubiquitylation of mitotic cyclins [18, 19]. Mdm2, initially thought to be a HECT domain variant, was shown in 1997 to have E3 activity towards p53 in vitro [20]. For the non-HECT E3s no common structural feature had been detected. Thus, by 1997 the only defined molecular signature for E3 activity was the HECT domain. 

Storteboom H, Arabi M, Davis JG et al (2010) Identification of antibiotic-resistance-gene molecular signatures suitable as tracers of pristine river, urban, and agricultural sources. Environ Sci Technol 44(6) 1947-1953... 

Cancer therapeutics — Different tumor types and the differentiated states of individual tumors are known to exhibit xmique gene expression patterns called molecular signatures or fingerprints. The molecular signature may be useful in tumor phenotype classification. 

Kallioniemi A. Molecular signatures of breast cancer predicting the future. N Engl J Med 2002 347 2067-2068. 

Ramaswamy S, Ross KN, Lander ES et al. A molecular signature of metastasis in primary solid tumors. 2003 33 49-54. 

Solomon, D., Lehmann, J.,Thies, J., Schafer,T., Liang, B., Kinyangi, J., Neves, E., Petersen, J., Luizao, F., and Skjemstad, J. (2007b). Molecular signature and sources of biochemical recalcitrance of organic C in Amazonian Dark Earths. Geochim. Cosmochim. Acta 71, 2285-2298. 

Fig. 8. The remnant molecular signature of the [2]catenane device, measured by varying the write voltage in 40 mV steps and by reading the device at —0.2 V.

The organization, cellular features and molecular signature, as well as the functional correlates of the circuits which utilize dopamine (DA) as neurotransmitter represent one of... 

Castillo J, Davalos A, Alvarez-Sabln J et al. (2002). Molecular signatures of brain injury after intracerebral hemorrhage. Neurology 58 624-629... 

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