Latent membrane proteins LMP

Sutkowski N, Chen G, Calderon G, Huber BT Epstein-Barr vims latent membrane protein LMP-2A is sufficient for transactivation of the human endogenous retrovims HERV-K18 superantigen. J Virol 2004 78 7852-7860. 

The latent membrane protein (LMP-1) is a viral protein that protects infected cells from apoptosis through up-regulation of BCL-2. As such, it serves as a marker of EBV infection. The correlation of LMP-1 by immuno-histochemistry to EBV RNA by in situ hybridization is reportedly good for many diseases but is poor for NK/T cell lymphomas. This may be attributable to the latency state of the virus. 

There is much more to this functional complexity than we have been able to discuss in this review. For instance, we have not touched on the complex intranuclear network mediated by the nuclear lamins, which is critically important for human health as reflected in the numerous disease phenotypes that are emerging due to mutation in lamins and their associated protein partners. We have also not discussed the association of IFs with molecules involved in bacterial and viral pathogenesis, such as the Ebstein-Barr virus latent infection membrane protein (LMP) (Liebowitz et al., 1987) or viral kinases such as the herpes simplex virus US3 kinase (Murata et at, 2002) that may be important in remodeling IFs during infection. It is clear, however, from the many critical cellular functions we have discussed in this review, that the IF structural and signaling scaffold is involved in wide-ranging functions that are important for fundamental... 

H/RSCs commonly express the EBV gene product latent membrane protein 1 (LMP-1), a transforming protein that can confer a growth advantage on H/RSCs. 

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