Lymphoplasmacytic lymphoma

BL, Burkitt lymphoma BLL, Burkitt-like lymphoma cHL, classical Hodgkin lymphoma IL, immunoblastic lymphoma LBL-B, lymphoblastic lymphoma precursor B-cell LBL-T, lymphoblastic lymphoma precursor T-cell LPL, lymphoplasmacytic lymphoma MM, multiple myeloma N, almost always negative PCLBL, primary cutaneous large B-cell lymphoma PEL, primary effusion lymphoma pHL, lymphocyte predominance Hodgkin lymphoma P-PTLD, polymorphic posttransplant lymphoproliferative disorders P-TCL, peripheral T-cell lymphoma PTLD, posttransplant lymphoproliferative disorders. 

The majority of these lymphomas demonstrate clonal immunoglobulin gene rearrangements. The most common cytogenetic abnormality identified in this lymphoma is deletions in the long arm of chromosome 6 (del(6)(q21)) with a small number of these lymphomas demonstrating t(9 14)(pl3 32). These translocations are not specific for lymphoplasmacytic lymphoma and have been demonstrated in other B-cell lymphomas. 

Flaviviridae the hepacivirus family is represented by its single member the hepatitis C virus. This important human hepatitis virus is reported to be associated with hepatocellular carcinoma, lymphoplasmacytic lymphoma, extranodal marginal zone B-cell lymphoma and monoclonal lymphoid proliferation. 

Hensel M, Villalobos M, Komacker M, Krasniqi F, Ho AD. Pentostatin/cyclophosphamide with or without rituximab an effective regimen for patients with Waldenstrom s macroglob-ulinaemia/lymphoplasmacytic lymphoma. Clin Lymphoma Myeloma (2005) 6,131-5. 

LIP is a clinicopathologic entity characterized by a very prominent cellular lymphoplasmacytic interstitial infiltrate. Although it is classified as an idiopathic interstitial pneumonia (3), it is rarely idiopathic and more often due to one of a variety of conditions including infections (especially Epstein-Barr virus, human immunodeficiency virus, and Pneumocystis jiroveci), chronic active hepatitis, CVD such as Sjogren syndrome and SLE, drug toxicity, immunodeficiency states, and after bone marrow transplantation (21,40-53). Primary B-cell lymphomas may develop in approximately 5% of patients with LIP associated with Sjogren syndrome (54). 

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