Chromatography low resolution mass spectrometry

In this core, concentrations of PCBs (determined as Aroclor 1254 and 1260, by high resolution gas chromatography, electron capture detection and high resolution gas chromatography-low resolution mass spectrometry) were <30 ng and those of total DDT (p,p DDT + p,p DDD + p,p DDE) <5 ng g Campesan et al. (21) in 11 sediment samples from Valle di Brenta, determined by GC-ECD the following mean concentrations (ng gd.w.) ... 

Gas chromatography-low resolution mass spectrometry was used to determine if TCDD is in the samples (12). The GC column used was a 6 ft. x 2 mm i.d. glass 2.5% BMBT liquid crystal on 100/120 mesh Chromosorb WHP (Altech Assoc.) at 225°C. In Figure 3 is shown the output from a standard and typical human milk extract run on an LKB-9000 with a SI-150 (System Industries) data system equipped with a computer controlled multiple ion detector (Ledland, Inc.). The entire extract was... 

Figure 3. Gas chromatography-low resolution mass spectrometry grams for 2,3,7,8-TCDD standard and human milk extract ((—...

Hummel, R. A., and Shadoff, L. A. (1980). Specificity of low resolution gas chromatography-low resolution mass spectrometry for the detection of tetrachlorobenzo-p-dioxin in environmental samples. Anal. Chem. 52, 191-192. 

This procedure ( ) has been used since 1982 by EPA for routine investigations. The analytical protocol requires complete extraction of the sample followed by liquid chromatographic cleanup and isomer-specific 2,3,7,8-TCDD analysis by high resolution gas chromatography/low resolution mass spectrometry. The extraction begins with ten grams of soil which is spiked with internal surrogate CI4-2378-... 

HIGH-RESOLUTION GAS CHROMATOGRAPHY-LOW-RESOLUTION MASS SPECTROMETRY (HRGC-LRMS)... 

US EPA (1998a) Polychlorinated Dibenzo-p-dioxins and Polychlorinated Dibenzofurans by High Resolution Gas Chromatography-Low Resolution Mass Spectrometry (HRGC-LRMS), US EPA Method 8280B, Rev. 2, January 1998. 

Huber, J.F.K., Kenndler, E., Reich, G. (1979). Quantification of the information content of multi-dimensional gas chromatography and low resolution mass spectrometry in the identification of doping drugs. J. Chromatogr. 172, 15-30. 

Bay, Massachusetts. Gas liquid chromatography was used to detect hydrocarbons present at different depths in the sediment, while low resolution mass spectrometry was employed to measure concentrations of paraffins, cycloparaffins, aromatics and polynuclear aromatics. Their data show that the concentrations of total and saturated hydrocarbons decreased with increased depth, and it was noted that identification and quantification of hydrocarbons in oil-contaminated sediments is required if the fate of these compounds in dredge spills is to be determined. 

Gas chromatography Liquid chromatography Infrared spectrometry Low resolution mass spectrometry... 

Cai, Z., V. Ramanujam, D. Giblin, M. Gross, and R. Spalding (1993). Determination of atrazine in water at low- and sub-parts-per-tril-lion levels by using solid-phase extraction and gas chromatography/high-resolution mass spectrometry. Anal. Chem., 65(1) 21-26. 

Covaci, A., de Boer, J., Ryan, J.J., Voorspoels, S., Schepens, P., 2002. Determination of polybrominated diphenyl ethers and polychlorinated biphenyls in human adipose tissue by large-volume injection-narrow-bore capillary gas chromatography/electron impact low-resolution mass spectrometry. Anal. Chem. 74, 790-798. 

PCDE analyses can be performed by high resolution gas chromatography (HRGC) combined with low resolution mass spectrometry (LRMS) or using HRGC combined with high resolution mass spectrometry (HRMS). For example, a Hewlett Packard 5970 mass selective detector system, which is a qua-drupole mass analyzer, has been used as an LRMS instrument in Finnish studies [33, 57, 113, 114, 122-125, 139]. Compared to LRMS, HRMS is more sensitive, allows less sample cleanup, and eliminates interference more effec-... 

The public health implications required a rapid, yet reliable assessment of these sites. A cost-effective procedure was developed to analyze for 2,3,7,8-TCDD down to 1 part per billion (ppb) in hundreds of soil samples ( ). From late 1982 thru 1985, over 13500 samples were analyzed by 50 different laboratories using procedures based on isotope dilution and high resolution gas chromatography with low resolution mass spectrometry. A comprehensive quality assurance program was implemented to assure the reliability of data generated during this massive monitoring effort ( 3). 

Beaume F, Coelhan M, Parlar H (2006) Determination of ClO-chloroalkane residues in fish matrices by short column gas chromatography/electron capture negative ion low resolution mass spectrometry applying single pure and representative synthesized chlorodecanes as standards. Anal Chim Acta 565 89-96... 

Low resolution mass spectrometry (MS), especially in tandem with gas chromatography, and nuclear magnetic resonance (NMR) spectroscopy have been reviewed with respect to their application to pesticide residue analysis. Sample preparation, direct probe MS analysis, GC-MS interface problems, spectrometer sensitivity, and some recent advances in MS have been studied. MS analyses of pesticide residues in environmental samples (malathion, dieldrin, dia-zinon, phenyl mercuric chloride, DBF, and polychlorinated biphenyls) have been illustrated. Fragmentation patterns, molecular ions, isotope peaks, and spectral matching were important in the identification of these pesticides. The sensitivity limitations of NMR and recent improvements in sensitivity are discussed along with examples of pesticide analyses by NMR and the application of NMR shift reagents to pesticide structure determinations. 

Low resolution mass spectrometry was performed by the Penn State Chemistry Department on a Kratos MS 9/50. Capillary gas chromatography was performed on a Hewlett-Packard 5880A Series GC. The capillary column used was a 12 m crosslinked methylsilicone fast analysis column utilizing a flame ionization detector. Helium was used as the carrier gas at a flow rate of 2.2 mL/min under various temperature programming conditions. 

Smith [83] classified large sets of hydrocarbon oil infrared spectral data by computer into correlation sets for individual classes of compounds. The correlation sets were then used to determine the class to which an unknown compound belongs from its mass spectral parameters. A correlation set is constructed by use of an ion-source summation, in which a low resolution mass spectrum is expressed as a set of numbers representing the contribution to the total ionisation of each of 14 ion series. The technique is particularly valuable in the examination of results from coupled gas chromatography-mass spectrometry of complex organic mixtures. 

Spitzer, V., Structure Analysis of Fatly Acids by Gas Chromatography-Low Resolution Electron Impact Mass Spectrometry of Their 4,4-Drmethyloxazoline Derivatives—A Review, Prog. Lipid Res. 35 387—408 (1997). 

Boon, J.J. and J.W. De Leeuv, Amino acid sequence information in proteins and complex proteinaceous material revealed by pyrolysis-capUlary gas chromatography low and high resolution mass spectrometry,/. Ana/. App/. Pyrol, 11 313-327 (1987). Mariner, W.N. and P. Magidman, Analysis of wool proteins by pyrolysis-gas chromatography, in Preprints of 198th ACS National Meeting, Miami, Florida, September 1989. 

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