Choriocarcinomas

MTX is part of curative therapeutic schedules for acute lymphoblastic leukemias (ALL), Burkitt s lymphoma, and choriocarcinoma. It was also used in adjuvant therapy of breast cancer. High dose MTX with leucovorin rescue can induce about 30% remissions in patients with metastatic osteogenic sarcoma. MTX is one of the few antineoplastic drugs that can be safely administered intrathecally for the treatment of meningeal metastases and leukemic infiltrations (routine prophylaxis in ALL). In addition, MTX can be used as an immunosuppressive agent for the treatment of severe rheumatoid arthritis and psoriasis. [Pg.148]

Cancer treatment is a multimodality treatment, i.e., surgery is combined with radiotherapy and antineoplastic chemotherapy. The latter treatment mode is used mainly for cancers which have disseminated. Different forms of cancer differ in their sensitivity to chemotherapy with antineoplastic agents. The most responsive include lymphomas, leukemias, choriocarcinoma and testicular carcinoma, while solid tumors such as colorectal, pancreatic and squamous cell bronchial carcinomas generally show a poor response. The clinical use of antineoplastic agents is characterized by the following principles. [Pg.157]

Boumah, C. E., et al. Functional expression of the nitrobenzylthioino-sine-sensitive nucleoside transporter of human choriocarcinoma (BeWo) cells in isolated oocytes of Xenopus laevis. Biochem. J. 1994, 299, 769-773. [Pg.275]

Kekuda, R., et al. Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. J. Biol. Chem. 1996, 273, 18657-18661. [Pg.276]

Rat mammary tumors Lewis lung cancers Mouse mammary tumors Choriocarcinoma cells Anaplastic sarcomas Walker carcinoma cells Rat prostatic carcinomas Rat embryo fibroblasts Different malignant cells... [Pg.146]

Rytting E and Audus KL (2005) Novel organic cation transporter 2-mediated carnitine uptake in placental choriocarcinoma (BeWo) cells. J Pharmacol Exp Ther 312(1) 192—198. [Pg.255]

The choriocarcinoma cell line JAr bears close resemblance to early trophoblast, as their secretion pattern of hCG and steroids is similar, and the cells can differentiate into syncytiotrophoblasts in vitro [71], In a study comparing efflux transporter expression and activity in trophoblast cell lines and choriocarcinoma cells, the expression profiles indicated that while BeWo are more... [Pg.376]

J.D. Aplin, A. Sattar, and A.P. Mould. Variant choriocarcinoma (BeWo) cells that differ in adhesion and migration on fibronectin display conserved patterns of integrin expression. J Cell Sci. 103 (Pt 2) 435 144 (1992). [Pg.390]

S.J. Friedman and P. Skehan. Morphological differentiation of human choriocarcinoma cells induced by methotrexate. Cancer Res. 39 1960-1967 (1979). [Pg.390]

P.A. Vardhana and N.P. Ulsley. Transepithelial glucose transport and metabolism in BeWo choriocarcinoma cells. Placenta. 23 653-660 (2002). [Pg.390]

F. Martel and E. Keating. Uptake of 1-methyl-4-phenylpyridinium (MPP+) by the JAR human placental choriocarcinoma cell line Comparison with 5-hydroxytryptamine. Placenta. 24 361-369 (2003). [Pg.391]

C. Wadsack, A. Hrzenjak, A. Hammer, B. Hirschmugl, S. Levak-Frank, G. Desoye, W. Sattler, and E. Malle. Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins. Eur J Biochem. 270 451 -62 (2003). [Pg.391]

R.S. Tuan, C.J. Moore, J.W. Brittingham, J.J. Kirwin, R.E. Akins, and M. Wong. In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. J Cell Sci. 98 (Pt 3) 333-342 (1991). [Pg.391]

M. Ceckova, A. Libra, P. Pavek, P. Nachtigal, M. Brabec, R. Fuchs, and F. Staud. Expression and functional activity of breast cancer resistance protein (BCRP, ABCG2) transporter in the human choriocarcinoma cell line BeWo. Clin Exp Pharmacol Physiol. 33 58-65 (2006). [Pg.395]

Sun T, Zhao Y, Mangelsdorf DJ, Simpson ER. 1998. Characterization of a region upstream of exon I.l of the human CYP19 (aromatase) gene that mediates regulation by retinoids in human choriocarcinoma cells. Endocrinology 139 1684-1691. [Pg.89]

Zevin S, Schaner ME, Giacomini KM (1998) Nicotine transport in a human choriocarcinoma cell line (JAR). J Pharm Sci 87 702-706... [Pg.60]

Methotrexate is used to treat severe lymphatic leukemia, choriocarcinoma, non-Hodgkin s lymphoma, bone carcinoma, as well as head, neck, breast, and lung tumors. Synonyms of this drug are farmitrexate, ledertrexate, ematexate, maxtrex, folex, mexate, and others. [Pg.391]

WARNING Chemo agent handle w/ caution Uses Hodgkin Dz NHLs, mycosis fungoides, CAs (testis, renal cell, breast, NSCLC), AIDS-related Kaposi sarcoma, choriocarcinoma, histiocytosis Action X Microtubule assembly Dose 0.1-0.5 mg/kg/wk (4-20 mg/m ) X in hepatic failure Caution [D, ] Contra IT use Disp Inj SE i BM (esp leukopenia), NA, constipation, neurotox, alopecia, rash, myalgia, tumor pain Interactions T Effects W/ erythromycin, itraconazole X effects W/ glutamic acid, tryptophan X effects OF phenytoin EMS T Risk of... [Pg.317]

Folic acid antagonists are of historical interest as a representative of this group, i.e. methotrexate, produced the first, although temporary, remissions in leukemia and the first cure of a solid tumor, choriocarcinoma. [Pg.451]

Clinical applications include childhood acute lymphoblastic leukemia, choriocarcinoma, osteosar-com, non-Hodgkin s lymphoma and Burkitt s lymphoma. However methotrexate is also frequently used as an immunosuppressant in diseases such as psoriasis, rheumatoid arthritis and others. [Pg.452]

Its mechanism of action is based on intercalation in the minor groove of double stranded DNA, interference with RNA polymerase and with topoiso-merase II. Its primary indications are rhabdomyosarcoma and Wilms tumor in children. In combination with methotrexate, it is used in the treatment of choriocarcinoma. [Pg.455]

Adult Hodgkin s disease Non-Hodgkin s disease Trophoblastic choriocarcinoma Testicular and ovarian germ cell cancers... [Pg.631]

Methotrexate is part of curative combination chemotherapy for acute lymphoblastic leukemias, Burkitt s lymphoma, and trophoblastic choriocarcinoma. It is also useful in adjuvant therapy of breast carcinoma in the palliation of metastatic breast, head, neck, cervical, and lung carcinomas and in mycosis fungoides. [Pg.643]

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