Organic cation transporter 1

Methly-4-phenyl-l, 2,3,6-tetrahydropytidine Organic Cation Transporters... [Pg.793]

The organic cation transporters (OCTs) facilitate the uptake of many cationic drugs across different barrier membranes from kidney, liver, and intestine... [Pg.505]

Bednarczyk D, Ekins S, Wikel JH and Wright SH. Influence of molecular structure on substrate binding to the human organic cation transporter, hOCTl. Mol Pharmacol 2003 63 489-98. [Pg.512]

Suhre WM, Ekins S, Chang C, Swaan PW and Wright SH. Molecular determinants of substrate/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2. Mol Pharmacol 2005 67 1067-77. [Pg.512]

Cell lines, such as the Caco-2 and MDCK cells [27, 35, 47, 49, 57, 67, 128-133], have been used frequently to study different transporters in the GI tract. These cell lines have been evaluated for transport both in absorptive and secretory direction and in addition also been transfected with specified transporter systems of interests to yield new clones [23, 31, 72, 79, 80, 134] or co-cultures [135], Some of the uptake transporters belonging to the organic cation transporter (OCT) family have also been identified in cell lines such as the pig kidney cell line LLC-PK1, and MDCK [67, 136]. In fact, its presence in Caco-2 cells needs to be further elucidated as reports have shown both the absence and presence of transporters from this family of transporters [136-138],... [Pg.114]

L. M., Feng, B., Giacomini, K. M., Functional characteristics and steroid hormone-mediated regulation of an organic cation transporter in Madin-Darby Canine Kidney cells, J. Pharmacol. Exp. Ther. 2001, 299, 392— 398. [Pg.124]

C. D., Characterization of MMP+ secretion across human intestinal Caco-2 cell monolayers role of P-glycoprotein and a novel Na+-dependent organic cation transport... [Pg.128]

The rate and extent of intestinal absorption of cimetidine has been widely discussed previously, and a reasonable value of fa for this drug has been estimated as 75% [90, 91]. It has been reported that cimetidine is a substrate for both P-gp and/ or organic cation transporters (OCNT1 and OCNT2) [82, 92]. We determined the... [Pg.171]

Organic cation transporters OCTs (3), OCTNs (3) SLC22A... [Pg.251]

Recently, considerable progress has been made in the cloning and functional characterization of organic cation transporters (OCTs) from many species and... [Pg.257]

Organic cation transporters OCT1/2 tetraethylammonium (TEA), thiamine,... [Pg.259]

Koepsell, H., V. Gorboulev, and P. Arndt. Molecular pharmacology of organic cation transporters in kidney. [Pg.277]

Koepsell, H. Organic cation transporters in intestine, kidney, liver, and brain. Annu. Rev. Physiol. 1998, 60, 243-266. [Pg.278]

Lahjouji, K., G. A. Mitchell, and I. A. Qureshi. Carnitine transport by organic cation transporters and systemic carnitine deficiency. Mol. Genet. Metab. 2001, 73, 287-297. [Pg.278]

Okuda, M., et al. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem. Biophys. Res. [Pg.278]

Kekuda, R., et al. Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J. Biol. Chem. 1998, 273, 15971-15979. [Pg.278]

Gorboulev, V., et al. Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell. Biol. 1997, 16, 871-881. [Pg.278]

Wu, X., et al. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim. Biophys. Acta 2000, 1466, 315-327. [Pg.278]

Ohashi, R., et al. Na(+)-dependent carnitine transport by organic cation transporter (OCTN2) its pharmacological and toxicological relevance. J. Pharmacol. Exp. Ther. 1999, 292, 778-784. [Pg.278]

K. M., Role of organic cation transporters in drug absorption and... [Pg.305]

See also in sourсe #XX -- [ Pg.505 ]

See also in sourсe #XX -- [ Pg.62 ]

See also in sourсe #XX -- [ Pg.301 ]

See also in sourсe #XX -- [ Pg.2 , Pg.104 ]

See also in sourсe #XX -- [ Pg.201 , Pg.235 , Pg.284 ]

See also in sourсe #XX -- [ Pg.64 , Pg.244 ]

See also in sourсe #XX -- [ Pg.873 , Pg.923 ]

See also in sourсe #XX -- [ Pg.115 , Pg.116 , Pg.117 , Pg.180 , Pg.180 , Pg.186 , Pg.186 ]

See also in sourсe #XX -- [ Pg.225 ]

See also in sourсe #XX -- [ Pg.362 ]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...