57-74-9 Chlordane

Chlordane is a wide-spectrum insecticide, and it is being phased out of use. It is classified as a probable human carcinogen (EPA Group B2). 

In an earlier study Kirby et al. (2001) investigated neurotoxicity of heptachlor in mice treated by intraperitoneal injection three times in 2-week period at dose levels of 

3-100 mg/kg. Their studies indicated that heptachlor exerted selective effects on striatal dopaminergic neurons and played a role in the etiology of idiopathic Parkinson s disease. 

White or light tan waxy solid with camphorlike odor melts at 95°C (203°F) boils at 135-145°C (275-293°F) (decomposes) vapor pressure 3 x 10 torr at 25°C (77°F) insoluble in water, soluble in most organic solvents. 

Highly toxic to animals toxic symptoms — tremors, convulsions, and liver necrosis also causes blood dyscrasias oral LD50 value (rats) 40 mg/kg caused liver cancers in mice no evidence of human carcinogenicity RCRA Waste Number P059 exposure limit TLV-TWA (skin) 0.5 mg/m (ACGIH). 

Exposure of laboratory animals to heptachlor has shown to alter the levels and 

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While solid m.p. 95 -96 - C, soluble in organic solvents. An insecticide similar to chlordane. Used to control cotton boll weevil. 

Cyclodienes. These are polychlorinated cycHc hydrocarbons with endomethylene-bridged stmctures, prepared by the Diels-Alder diene reaction. The development of these insecticides resulted from the discovery in 1945 of chlordane, the chlorinated adduct of hexachlorocyclopentadiene and cyclopentadiene (qv). The addition of two Cl atoms across the double bond of the ftve-membered ring forms the two isomers of chlordane [12789-03-6] or l,2,4,5,6,7,8,8-octachloro-2,3,3t ,4,7,7t -hexahydro-4,7-methano-lJT-indene, QL-trans (mp 106.5°C) and pt-tis (32) (mp 104.5°C). The p-isomerhas signiftcantiy greater insecticidal activity. Technical chlordane is an amber Hquid (bp 175°C/267 Pa, vp 1.3 mPa at 25°C) which is soluble in water to about 9 fig/L. It has rat LD qS of 335, 430 (oral) and 840, 690 (dermal) mg/kg. Technical chlordane contains about 60% of the isomers and 10—20% of heptachlor. It has been used extensively as a soil insecticide for termite control and as a household insecticide. 

Polychlorinated Pesticides. A once substantial but now diminished use for DCPD is in the preparation of chlorinated derivatives for further use or synthesis into pesticide compounds (see Insectcontrol technology). Soil permanence and solubiUty of the products in human fatty tissues have considerably restricted the use of these compounds. The more prominent chlorinated pesticides were aldrin, dieldrin, chlordane, and heptachlor, all of which use hexachorocyclopentadiene as a starting material. Aldrin and dieldrin are no longer used in the U.S. Chlordane and heptachlor are stiU produced, but only for export use. 

A number of other chemicals suspected of having endocrine disrupting potential also occur at high levels in the tissues of marine mammals. For example, tribiityltin compounds are present in the tissues of the Steller sea lion (Eumetopias juhatus) from Hokaido, Japan, and in stranded bottlenose dolphins (Tursiops truncatus) found along the US Atlantic and Gulf coasts.Additional chemicals detected include PAHs, toxaphene and chlordane. ... 

DOD/USAF chlordane assessments NASA HVAC system maintenance... 

Investigates USAF facilities for chlordane problems Assesses and corrects HVAC operation to optimize indoor air quality... 

Chlordane zero 0.002 Liver or nervous system problems increased risk of cancer Residue of banned termiticide... 

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