Organochlorine pesticides chlordane

Williams, G.M. and S. Numoto. 1984. Promotion of mouse liver neoplasms by the organochlorine pesticides chlordane and heptachlor in comparison to dichlorodiphenyltrichloroethane. Carcinogenesis 5 1689-1696. 

Telang S, Tony C, Williams GM. 1982. Epigenetic membrane effects of a possible tumor promoting type on cultured liver cells by the non-genotoxic organochlorine pesticides chlordane and heptachlor. Carcinogenesis 3 1175-1178. 

Hematological Effects. A questionnaire survey revealed that 4% of persons living in homes treated with chlordane to control termites reported anemia as a chronic effect (Menconi et al. 1988). The effect cannot be attributed to chlordane alone, because the quantitative amounts of aldrin and heptachlor were combined with the chlordane measurement in the analysis of indoor air. A number of anecdotal reports of blood dyscrasia associated with organochlorine pesticides (chlordane. 

Wilson and co-workers [332, 333] have discussed the determination of aldrin, chlordane, dieldrin, endrin, lindane, o,p and p,p isomers of DDT and its metabolites, mirex, and toxaphene in seawater and molluscs. The US environmental Protection Agency has also published methods for organochlo-rine pesticides in water and wastewater. The Food and Drug Administration (USA) [334] has conducted a collaborative study of a method for multiple organochlorine insecticides in fish. Earlier work by Wilson et al. [333, 335] in 1968 indicated that organochlorine pesticides were not stable in seawater. 

Loganathan, B.G., S. Tanabe, M. Goto, and R. Tatsukawa. 1989. Temporal trends of organochlorine residues in lizard goby Rhinogobius flumineus from the River Nagaragawa, Japan. Environ. Pollut. 62 237-251. Ludke, J.L. 1976. Organochlorine pesticide residues associated with mortality additivity of chlordane and endrin. Bull. Environ. Contam. Toxicol. 16 253-259. 

Cyclodiene pesticides, of which endrin and its oxidized analogs are representative, can also be estimated by receptor-assay technique. Cyclodiene pesticides exert their mode of action by altering central nervous system membrane ion transport. In work reported by Saleh et al. (1993), a labeled amino acid, GABA, that binds to the chloride channel receptor is displaced by endrin (and other similar molecules), and thus serves as an assay for these pesticides. The GABA receptor was shown to be a potentially useful biomarker for organochlorine pesticides such as lindane, toxaphene, endrin, chlordane, and others. The assay involves small quantities of blood (0.1 mL), and requires only that the plasma be separated from the... 

Ludke JL. 1976. Organochlorine pesticide residues associated with mortality Additivity of chlordane and endrin. Bull Environ Contain Toxicol 16 253-260. 

Organochlorine pesticides (e g., chlordane. dieldrin) Pesticide manufacture and agricultural applications Bone marrow... 

Organochlorine pesticides were predominantly used during the 1950s-1970s in China. DDT, HCH, toxaphene, HCB, chlordane, heptachlor, and mirex used to be produced in China. Historically, there have been 60 POP pesticide-producing enterprises, which were located in 18 provinces in China. 

In 1997, the United Nations Environment Programme (UNEP) Governing Council decided that immediate international action should be taken to protect human health and the environment. International negotiations to reduce and eliminate the emission and discharges of an initial set of 12 POPs were initiated at the Stockholm Convention on POPs in May 2001. The 12 substances that were addressed at the Stockholm Convention were aldrin, endrin, dieldrin, dichlorodiphenyltrichoroethanes (DDTs), polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), chlordane, toxaphene, heptachlor, hex-achlorobenzene (HCB) and mirex. Basic information and status of major organochlorine pesticides in China are summarized in Table 8.1. 

Chlordane was introduced as an insecticide in 1945 and was the first cyclodiene insecticide that was used in agriculture (Eisler, 1990). It was the second most important organochlorine pesticide after toxaphene from 1976 to 1977 (Stansley Roscoe, 1999). It has been used on agricultural crops and extensively in the control of termites (Smith, 1991). Chlordane and heptachlor can be metabolized into two persistent (oxygenated) epoxides—oxychlordane and heptachlor epoxide—in mammals (Nomeir Hajjar, 1987) such that the two compounds are always measured together with chlordane and heptachlor. 

Figure 4.13 Variability in enantiomer fractions (EFs) of cis-chlordane and trans-chlordane at plots In grassland (G) and woodlands (W1 and W2) In Scotland. Box plot defined as follows top and bottom of whiskers are maximum and minimum EFs, respectively top and bottom of box are 25 and 75% percentiles, respectively line in box is median EF. (Reproduced with permission from Environmental Science and Technology, Enantioselective Degradation of Organochlorine Pesticides In Background Soils Variability In Field and Laboratory Studies, by Perihan Binnur Kurt-Karakus, Jacqueline L. Stroud et af, 41(14), 4965-4971. Copyright (2007) American Chemical Society)...

Leone, A.D., Ulrich, E.M., et al (2000) Organochlorine pesticide concentrations and enandomer fractions for chlordane in indoor air from the US combelt. Atmospheric Environment, 34(24) 4131 138. 

The trace enrichment of pesticides from groundwater is a straightforward problem for reversed-phase SPE. The following example uses the EMPORE disk (C-18) to isolate organochlorine pesticides including aldrin, chlordane, endrin, heptachlor, lindane, methoxychlor, pentachlorophenol, and toxaphene from groundwater (Fig. 4.15). 

E.A. Maier., L.G.M.Th. Tuinstra., A.H. Roos and B. Griepink, Certification of the contents (mass fraction) of organochlorine pesticides (heptachlor, -heptachlorepoxide, y-chlordane, a-endosulfan, aldrin, dieldrin, endrin. o,p -DDT and p.p -DDT) inanimal feed— CRM 115. Report EUR 16889EN, European Commission, Luxembourg (1996). 

The stability of the organochlorine pesticides in the cod liver oil was studied at three temperatures (-20°C, +20°C and +40 C) after 1, 3, 6 and 12 months, using the same method as applied in the homogeneity study. Due to an interference with toxaphene, the results of the measurement of y-chlordane were found to be unrealistic. Therefore, the stability of this compound could not be demonstrated. As for o,p -DDE the origin of the unreliability of the results is due to the instability of o,p -DDT in the analytical system, both compounds were not considered for certification. For the remaining OCPs no instability could be demonstrated. 

Organochlorine pesticides include aldrin, chlordane, dichophane (DDT), dieldrin (also a metabolite of aldrin) endrin heptachlor, hexachlorobenzene (EICB), 1, 2, 3, 4, 5, 6-hexachlorocyclohexane (EICEI = benzenehexachloride, BE1C), and lindane (gamma - EICEI). These compounds were widely used but persist in the environment, and lindane, which has a relatively short half-life in vivo, is now the only member of this group still in common use. Pentachlorophenol is used as a contact herbicide. This compound is still widely used in wood preservatives and disinfectants. 

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