Mutagenicity chlordane

Negative results for mutagenicity of d.v-chlordanc and tran.v-chlordanc were reported in various strains of bacteria and in hepatocyte cultures of small mammals. But technical chlordane proved mutagenic to selected strains of Salmonella typhimurium and induced gene conversions in certain strains of the yeast, Saccharomyces cervisiae (IARC 1979 USEPA 1980, 1988 WHO 1984). 

Epstein SS, Ozonoff D. 1987. Leukemias and blood dyscrasias following exposure to chlordane and heptachlor. Teratogenesis Carcinog Mutagen 7 527-540. 

Chlordane was not mutagenic to bacteria/ The 2003 ACGIH threshold limit valuetime-weighted average (TLV-TWA) for chlordane is 0.5mg/m with a notation for skin absorption and an A3-confirmed animal carcinogen with unknown relevance to humans designation. 

Chlordane Generalized convulsions, reproductive toxicity, birth defects, loss of consciousness, change in EEG pattern, hepatic disorders, neurologic disturbances, mutagenicity, carcinogenicity... 

Chronically, symptoms include anemia, leukopenia, thrombocytopenia, jaundice, and abnormal blood serum chemistry results. Reproductive or teratogenic effects do not appear to be present. Mutagenicity testing generally indicates that chlordane is not mutagenic. Chlordane is classified as group 2B (possibly carcinogenic to humans) by the lARC. 

Chambers C, Dutta SK. 1976. Mutagenic tests of chlordane on different microbial tester strains [Abstract]. Genetics 3 13. 

Tsushimoto G, Chang CC, Trosko JE, et al. 1983. Cytotoxic, mutagenic, and cell-cell communication inhibitory properties of DDT, lindane, and chlordane on Chinese hamster cells in vitro. Arch Environ Contam Toxicol 12 721-729. 

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