Deficiency effects chlordane

Chlordane interacts with other chemicals to produce additive or more-than-additive toxicity. For example, chlordane increased hepatotoxic effects of carbon tetrachloride in the rat (USEPA 1980 WHO 1984), and in combination with dimethylnitrosamine acts more than additively in producing liver neoplasms in mice (Williams and Numoto 1984). Chlordane in combination with either endrin, methoxychlor, or aldrin is additive or more-than-additive in toxicity to mice (Klaassen et al. 1986). Protein deficiency doubles the acute toxicity of chlordane to rats (WHO 1984). In contrast, chlordane exerts a protective effect against several organophosphorus and carbamate insecticides (WHO 1984), protects mouse embryos against influenza virus infection, and mouse newborns against oxazolone delayed hypersensitivity response (Barnett et al. 1985). More research seems warranted on interactions of chlordane with other agricultural chemicals. 

The acute toxicity of chlordane in rats increased when rats were fed protein deficient diets (Boyd and Taylor 1969). Chlordane treatment has also been demonstrated to enhance the hepatotoxic effects produced by carbon tetrachloride in rats, as indicated by its effect on SGPT levels, presumably by inducing the metabolism of carbon tetrachloride to its toxic metabolite (Mahon et al. 1978 Stenger et al. 1975). On the other hand, chlordane provided some protection against carbon tetrachloride-induced liver necrosis in rats, possibly by inducing a type of cytochrome P-450 with diminished ability to metabolize carbon tetrachloride to its toxic metabolite (Mahon et al. 1978). Pretreatment of rats with chlordane accelerated the metabolism of lindane, presumably by the same mechanism (Chadwick et al. 1977). 

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