B lymphocytes differentiation

TCDD suppression of B lymphocyte differentiation by competing for binding to the Ah receptor. The mechanism of interaction of these chemicals was studied in vitro using rat hepatic cytosol or mouse hepatoma cells (Gasiewicz and Rucci 1991). The results indicated that -naphthoflavone acts as a... 

During B-lymphocyte differentiation, one of the 300 or so V regions becomes joined precisely to one of the J gene segments to create a light chain gene. This... 

Rozing J, Buuraman WA, Benner R. 1976. B lymphocyte differentiation in lethally irradiated and reconstituted mice. Cell Immunol 24 79-89. 

In order to fully understand the complex biochemical mechanisms by which the thymus and its hormones control the expression of immunity, it is first necessary to review briefly the organization of the thymus-dependent (T cell) immune system (Fig. I). The predominant cells of the peripheral lymphoid tissue (i.e., spleen, lymph nodes) includes both B and T lymphocytes. In the presence of foreign antigens, B lymphocytes differentiate into plasma cells, which in turn synthesize antibody thus, B cells make up the humoral arm of the immune system. In contrast, T lymphocytes are responsible for mediating all the classical cellular immune responses such as delayed type hypersensitivity skin responses, organ transplant rejections, and sensitized antitumor immunity as well as immunity toward various viral, fungal, and protozoal pathogens (Reinherz and Schlossman, 1980). 

B41. Bich Thuy, L. T. High-aBinity receptors for interleukin-2 are not required for the induction of human unstimulated B lymphocyte differentiation by this lymphokine. Cell. Immunol. 128,... 

In virtually all cells, transposons use recombination to move within or between chromosomes. In vertebrates, a programmed recombination reaction related to transposition joins immunoglobulin gene segments to form immunoglobulin genes during B-lymphocyte differentiation. 

Production of antisera does not require specialized immunological techniques and cell culture facilities. Therefore it may be a simpler, faster and cheaper way than production of monoclonal antibodies (see section 3.3.). However, it must be noted that antisera-based immunoassays are sometimes less selective than monoclonal antibody-based immunoassay because of the polyclonality of antibodies in the antisera, and good antisera are not reproduced. The production of high affinity antisera may be helped by long-term immunization schedules from the mechanism of antigen-dependent B lymphocyte differentiation and selection (23). 

Jehnek DF. Regulation of B lymphocyte differentiation. Aim Allergy Asthma Immunol 2000 84(4) 375-385. 

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