Eosinophil recruitment

Fujiwara M, Hirose K, Kagami S. Takatori H. Waka-shin H, Tamachi T, Watanabe N. Saito Y. Iwamoto I. Nakajima H T-bet inhibits both Th2 cell-mediated eosinophil recruitment and Th17 cell-mediated neutrophil recruitment into the airways. J Allergy Chn Immunol 2007 119 662-670. 

Chensue SW, Lukacs NW, Yang TY, et al. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 2001 193(5) 573-584. 

Fig. 6.1 Immediate hypersensitivity reaction. These reactions are the result of the production of IgE antibody in response to an allergen. IgE binds to the mast cells via Fc receptors and its reexposure to the allergen causes degranulation and secretion of endogenous mediators. In allergic responses, TH2 cells are important in recognizing allergens in the context of MHC molecules and secrete IL-4, IL-5 and IL-13. IL-4 induces isotope switching from IgG to IgE, and IL-5 is involved in eosinophil recruitment. IL-8 serves as a chemical signal to attract neutrophils at the site of inflammation. The collective effects of endogenous mediators include rashes, inflammation, smooth-muscle contraction, bronchospasm, asthma and severe anaphylactic shock, which may even cause death (see Color Insert)...

K6. Kumano, K., Nakao, A., Nakajima, H., Hayashi, F., Kurimoto, M., Okamura, H., Saito, Y., and Iwamoto, I., Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways. Am. J. Respir. Crit. Care Med. 160, 873-878 (1999). 

Mochizuki, M Bartels, J., Mallet, A. I., Christophers, E., and Schroder, J. M. (1998) IL4 induces eotaxin a possible mechanism of selective eosinophil recruitment in helminth infection and atopy. J. Immunol. 160, 60-68. 

Macrophage inflammatory protein-1 alpha influences eosinophil recruitment in antigen-specific airway inflammation. Eur. J. Immunol. 25, 245-251. 

In general, the labeling efficiency is > 80%. Clearly, it is desirable to have a low level of11 indium free in the plasma, otherwise plasma extravasation will contribute significantly to the measurement of mIn-eosinophil recruitment. 

Michel L, De Vos C, Rihoux JP, Burtin C, Benveniste J, Dubertret L. Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. J Allergy Clin Immunol 1988 82(l) 101-9. 

Mechanism of Selective Eosinophil Recruitment into the Airways 87... 

Nakajima, H., Iwamoto, I. and Yoshida, S. (1993). Aerosolized recombinant interferon-gamma prevents antigen-induced eosinophil recruitment in mouse trachea. Am. Rev. Respir. Dis. 148, 1102-1104. 

Rankin SM, Conroy DM, Williams TJ. Eotaxin and eosinophil recruitment implications for human disease. Mol Med Today 2000 Jan 6 20-7. 

If the mice are sensitized epicutane-ous]y with the same antigen, a diminished AHR response and eosinophil recruitment is obsQved (138). In the i.p. sensitized mice thoe is a significant mobilization of mast cells intD the airway epithelium, but not into the skin. These results suggest that the mechanism of induction of AHR might be different, depending on the route of sensitization. 

Gonzalo JA, Lloyd CM, Kremer L, Finger E, Martinez AC, Siegelman MH, Cybulsky M, Gutierrez-Ramos JC (1996) Eosinophil recruitment to the lung in a murine model of allergic inflammation. The role of T cells, chemokines, and adhesion receptors. J Clin Invest 98 2332-2345... 

RESNICK, M.B. WELLER, P.F. (1993) Mechanisms of eosinophil recruitment. American Journal of Respiratory Cell and Molecular Biology, 8, 349-355. 

ROBINSON, D.S., HAMID, Q BENTLEY, A., YING, S KAY, A.B. DURHAM, S.R. (1993) Activation of CD4+ T cells, increased Th2-type cytokine mRNA expression and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. Journal of Allergy and Clinical Immunology, 92, 313-324. 

Binds to CCR3 receptor chemoattracts eosinophils plays a key role in the regulation of eosinophil recruitment in asthmatic lung and allergic reactions... 

---