Cephalothin gentamicin

Cabanillas F, Burgos RC, Rodriguez C, Baldizon C. Nephrotoxicity of combined cephalothin-gentamicin regimen. Arch Intern Med 1975 135(6) 850-2. 

Salem PA Jabboury KW, Khalil MF. Severe nephrotoxicity a probable conplication of cis-dichlorodiammineplatinum (II) and cephalothin-gentamicin therapy. Oncology (1982) 39,... 

CLX cloxacillin, CEP cephalothin, STR dihydrostreptomycin, GEN gentamicin, NEO neomycin, NOV novobiocin, PEN penicillin, TET tetracycline, POB pol3miyxin B One research herd of about 180 milking cows... 

Dopamine is degraded by alkaline preparation and is incompatible with sodium bicarbonate solutions, furosemide, ampicillin, amphotericin, gentamicin sulfate, cephalothin sodium, oxacillin sodium, and thiopentone sodium. Percussion or excessive heat may cause an explosion with undiluted erythrityl tetranitrate. Care must be exercised to avoid contact with skin, eyes, and mucous membranes when handling ethacrynic acid. Sodium ethacrynate solutions are incompatible and less stable at very high pH, below pH 5, and at higher temperatures. 

Heparin and its salts are incompatible with many drugs including alteplase, amikacin sulfate, amiodarone hydrochloride, ampicillin sodium, aprotinin, benzylpenicillin potassium or sodium, cephalothin sodium, ciprofloxacin lactate, cytarabine, dacarbazine, daunorubicin hydrochloride, diazepam, dobutamine hydrochloride, doxorubicin hydrochloride, droperidol, erythromycin lactobionate, gentamicin sulfate, haloperidol lactate, hyaluronidase, hydrocortisone sodium succinate, kanamycin sulfate, methicillin sodium, netilmicin sulfate, some opioid analgesics, oxytetracycline hydrochloride, some phenothiazines, polymyxin B sulfate, streptomycin sulfate, tetracycline hydrochloride, tobramycin sulfate, vancomycin hydrochloride, vinblastine sulfate, cisatracurium besylate, labetalol hydrochloride, nicardipine hydrochloride, cefmetazole, sodium ions, and fat emulsion.110 112... 

Bailey RR. Renal failure in combined gentamicin and cephalothin therapy. BMJ 1973 2(5869) 776-7. 

The combination of cephalothin wifh an aminoglycoside was more nephrotoxic than methicillin plus aminoglycoside [143]. There is good evidence that concurrent administration of cephalothin and gentamicin are additive nephrotoxins in humans, especially in patients over 60 years of age as wells as in rabbits [144], and renal injuries are intensified in the presence of mild renal ischemia or endotoxemia [108]. The results of prospective randomized comparative studies of the combination mezlocillin/cefotaxime versus gentamicin/cefoxitin showed that the concurrent administration of mezlocillin/cefotaxime has low renal toxicity and can be recommended for the rational and empirical treatment of serious systemic infections [145]. 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, ampicil-lin, carbamazepine, cefamandole, cefazolin, cefoperazone, cefotaxime, cefoxitin, ceftazidime, ceftizoxime, cephalexin, cephalothin, cephapirin, chloramphenicol, ciprofloxacin, clonazepam, (yclosporine, desipramine, digoxin, disopyramide, ethosuximide, gentamicin, haloperidol, imipramine, kanamycin, lidocaine, mezlocillin, netilmicin, nortriptyline, phenobarbital, phenytoin, primidone, procainamide, propranolol, quinidine, salicylic acid, streptomycin, sulfamethoxazole, theophylline, thiamphenicol, ticarcillin, tobramycin, trimethoprim, vancomycin... 

Fanning WL, Gump D, Jick H. Gentamicin- and cephalothin-associated rises in blood urea nitrc en. Antimicrob Agents Chemother (1976) 10, 80-82. 

Gonzalez-Vitale JC, I es DM, Cvitkovic E, Stembei SS. Acute renal failure after m-Dichlorodiammineplatiinim ( ) and gentamicin-cephalothin therapies. Cancer Treat Rep (1978) 62,693-8. 

M. Mork-Hansen and K. Kaaber, Nephrotoxicity in Combined Cephalothin and Gentamicin Therapy, Acta. Med. Scand. 201, 463 67 (1977). 

Noninterfering ampicillin, cefazolin, cephalothin, cephapirin, chlorotheophylline, 1,3-di-methyluric acid, gentamicin, lidocaine, methicillin, methylurea, 3-methyluric acid, quin-idine, sulfamerazine, 1,3,7-trimethyluric acid... 

Rifampicin was found to be more active than cephalo-ridine, cephalothin lincomycin and gentamicin against gram-positive bacteria, it showed no cross resistance with other antibiotics Rifampicin was as active as streptomycin... 

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