Gentamicin Cefoxitin

Pelvic Inflammatory Disease Cefotetan or cefoxitin with doxycycline 1. Clindamycin with gentamicin 2. Ampicillin-sulbactam with doxycycline 3. Ciprofloxacin with doxycycline and metronidazole... 

Appendectomy prior to procedure) IV cefoxitin 1-2 g Cefoxitin 1-2 g IV Metronidazole 0.5-1 g IV plus gentamicin... 

The answer is e. (Hardman, pp 1092-10945 Cefoxitin and cefmeta-zole are suitable for treating intraabdominal infections. Such infections are caused by mixtures of aerobic and anaerobic Gram-negative bacteria like B. fragilis. Cefoxitin alone has been shown to be as effective as the traditional therapy of clindamycin plus gentamicin. 

Pelvic inflammatory Cefotetan or cefoxitin with doxycy- 1. Clindamycin with gentamicin... 

NaCIO is an acknowledged novel absorption enhancer for ampicillin sodium [99], glycyr-rhizin [100,101], gentamicin [102], phenoxymethyl penicillin [103], cefoxitin sodium [104,105], and acyclovir [106], Takahashi et al. [107] reported that the enhanced membrane permeability of phenolsulfonphthalein depends on the disappearance kinetics of CIO from the loop and its calcium ion sequestration capacity. The enhancing mechanisms of NaCIO are proposed to be involved in (1) Ca2+ sequestration, (2) increase in pore size and solvent drag, (3) interaction with membrane proteins and lipids, and (4) increase in the intracellular calcium level [104,105,108-111],... 

The combination of cephalothin wifh an aminoglycoside was more nephrotoxic than methicillin plus aminoglycoside [143]. There is good evidence that concurrent administration of cephalothin and gentamicin are additive nephrotoxins in humans, especially in patients over 60 years of age as wells as in rabbits [144], and renal injuries are intensified in the presence of mild renal ischemia or endotoxemia [108]. The results of prospective randomized comparative studies of the combination mezlocillin/cefotaxime versus gentamicin/cefoxitin showed that the concurrent administration of mezlocillin/cefotaxime has low renal toxicity and can be recommended for the rational and empirical treatment of serious systemic infections [145]. 

Viotte G, Morin GP, Godin M, Fillastre JP. Chamges in the renal function of rats treated with cefoxitin and a comparison with other cephlosporinsand gentamicin. J Antimicrob Chemother 1981 7(5) 537-550... 

Kosmidis J, Daikos GK. Prospective randomized comparative studies of mezlocillin/cefotaxime vs. gentamicin/cefoxitin. J Anti-microb Chemother 1983 11 (SuppI C) 91 -95. 

Aminoglycosides gentamicin, tobramycin, and amikacin use per sensitivities. Cefoxitin, cefotetan. 

McDonald PJ, Karran SJ. A comparison of intravenous cefoxitin and a combination of gentamicin and metronidazole as prophylaxis in colorectal surgery. Dis Colon Rectum 1983 26 661-664. 

Imipenem or meropenem amoxicillin/clavulanic acid ticarcillin/clavulanic acid piperacillin/tazobactam ampicillin/sulbactam cefoxitin cefotetan chloramphenicol cefmetazole penicillin G gatifloxacin or moxifloxacin Gentamicin... 

Cefoxitin or cefotetan gentamicin or clindamycin -i- gentamicin Cefazolin... 

Paap, C.M. Nahata, M.C. A novel micromethod for the simultaneous analysis of cefotaxime and desa-cetylcefotaxime from plasma using ion pair high performance liquid chromatography. J.Liq.Chromatogr., 1989, 12, 2385-2395 [plasma cefoxitin (IS) also acetaminophen, caffeine, cefazolin, methicillin, theophylline, vancomycin non-interfering ampicillin, gentamicin, ibuprofen, phenobarbital]... 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, ampicil-lin, carbamazepine, cefamandole, cefazolin, cefoperazone, cefotaxime, cefoxitin, ceftazidime, ceftizoxime, cephalexin, cephalothin, cephapirin, chloramphenicol, ciprofloxacin, clonazepam, (yclosporine, desipramine, digoxin, disopyramide, ethosuximide, gentamicin, haloperidol, imipramine, kanamycin, lidocaine, mezlocillin, netilmicin, nortriptyline, phenobarbital, phenytoin, primidone, procainamide, propranolol, quinidine, salicylic acid, streptomycin, sulfamethoxazole, theophylline, thiamphenicol, ticarcillin, tobramycin, trimethoprim, vancomycin... 

Noninterfering amikadn, carbenicillin, cefazolin, cefoperazine, cefoxitin, chloramphenicol, ciprofloxacin, gentamicin, imipenem, moxalactam, oxacillin, ticeircillin, tobramycin, vancomycin... 

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

The nephrotoxicity of various combinations of antibiotics was assessed in 171 cancer palienls. In Ihose receiving an aminoglycoside with a third generation cephalosporin, the most nephrotoxic combinations were found to be gentamicin with cefotaxime (although another study did not find this combination to be nephrotoxic ) and amikacin with ceftriaxone, where 5 of 20 and 5 of 13 patients, respectively, had increased serum creatinine. The following combinations were found to be safer amikacin with cefoxitin or ceftazidime, gentamicin with cefoxitin, and netilmicin with cefotaxime. ... 

Another study assessing the risk factors for nephrotoxicity with aminoglycosides (tobramycin and gentamicin) enrolled 1489 patients, 157 of whom developed clinical nephrotoxicity. Of these patients 118 had no immediately identifiable cause (such as acute renal failure) and further evaluation of other risk factors found that the concurrent use of cephalosporins (including cefazolin, cefotaxime, cefoxitin, cefamandole, ce-furoxime, ceftriaxone, and ceftazidime) significantly increased the risk of nephrotoxicity. ... 

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