Ethacrynate sodium

Powder for Injection 50 mg (as ethacrynate sodium) per vial (Rx) Edecrin Sodium (Merck)... 

Loop diuretics ethacrynate sodium ethacrynic acid furosemide... 

Etafedrine hydrochloride, 589 Etamiphylline, 590 Etamiphylline camsylate, 590 Etamivan, 593 Etamphyllin, 590 Etamyl, 353 Etaphylline, 310 Etebenecid, 595 Etenzamide, 590 Ethacridine, 591 Ethacridine lactate, 591 Ethacrynate sodium, 591 Ethacrynic acid, 591 Ethambutol, 592 Ethambutol hydrochloride, 592 Ethamide, 602 Ethaminal sodium, 863 Ethamivan, 593 Ethamolin, 594 Ethanal, 311 Ethanediol, 603 Ethanol, 593 assay kit, 1171 quantification, 19 Ethanol, denatured, 593 Ethanolamine, 594... 

Sodium salt, C H ( C1 jNaO, ethacrynate sodium, Lyovac Sodium Edecrin- uv max (water) 22S nm (e 15,287) Soly in water at 25° up tn 9%- Solns at pH 7 at 25° stable for short periods of time. Stability decreased with an increase in pH. temperature and time. 

Similar to furosemide. Narrower dose-response curve than furosemide. Increased azotemia in patients with renal disease taking tetracycline. Ethacrynate sodium is used intravenously to treat acute pulmonary edema. 

The effect of storage conditions on the crystalline nature of lyophilized ethacrynate sodium has been reported [37]. Samples of the drug substance were dried to various moisture levels and then stored at either 60°C or 30°C/75% RH. It was found that crystalline drug substance was obtained after short periods of time as long as sufficient levels of water were either present in the initial lyophilized solid or introduced by adsorption of humidity. The crystalline form of the drug was identified as a monohydrate phase. 

Acetazolaiilde Tablets Azathioprine Tablets Azathioprine Sodiuii for Injection Chlorothiazide Tablets Oichlorphenaaide Tablets Ethacrynate Sodium for Injection Ethacrynic Acid Tablets... 

Methohexital sodium Butyramidophenol Acebutolol Butyric anhydride lopanoic acid Tyropanoate sodium n-Butyryl chloride Ethacrynic acid... 

The loop diuretics, furosemide (Lasix) and ethacrynic acid (Edecrin), increase the excretion of sodium and chloride by inhibiting reabsorption of these ions in the... 

Procedure Weigh accurately about 0.2 g of ethacrynic acid, dissolve in 40 ml of glacial acetic acid in a 250 ml iodine flask. Add to it 20 ml of 0.1 N bromine and 30.0 ml of hydrochloric acid, immediately place in position the moistened stopper to the ffask, mix the contents vigorously and allow it to stand in a dark place for 60 minutes (to complete the reaction with bromine). Add to it 100 ml of water and 20 ml of KI Solution and titrate immediately with 0.1 sodium thiosulphate, employing freshly prepared starch solution as an indicator towards the end of the titration. Repeat an operation without the pharmaceutical substance (blank titration) thus the difference between the titrations represents the amount of bromine required by the ethacrynic acid. Each ml of 0.1 N bromine is equivalent to 0.01516 g of C13H12C1204. 

Most of the lithium is eliminated in the urine, the first phase of the elimination being 6-8 hours after administration, followed by a slower phase which may last for 2 weeks. Sodium-depleting diuretics such as frusemide, ethacrynic acid and the thiazides increase lithium retention and therefore toxicity, while osmotic diuretics as exemplified by mannitol and urea enhance lithium excretion. The principal side effects of lithium are summarized in Table 8.1. 

It has also become more evident that the loop of Henle is of major importance in the regulation of sodium and water balance, and in agreement with this, both frusemide (furosemide, fursemide, Lasilix, Lasix) and ethacrynic acid (XXIII... 

Drugs acting only on the distal tubule (however complete the resulting block of sodium resorption at that site) are limited, in the effect obtainable, by the comparatively small contribution to total sodium reclamation made by this portion of the nephron. For example, even at their activity peak, thiazide diuretics cause the elimination of only 8 per cent of the total filtered sodium [302, 303] Very much higher proportions of filtered sodium would be expected to contribute to diuresis if the mechanisms of the loops of Henle could be blocked (this has, in fact, proved to be the case in that frusemide and ethacrynic acid are both capable of clearing up to 20 per cent of filtered sodium [302, 304-6]). 

Pharmacoiogy Furosemide and ethacrynic acid inhibit primarily reabsorption of sodium and chloride, not only in proximal and distal tubules, but also the loop of Henle. In contrast, bumetanide is more chloruretic than natriuretic and may have an additional action in the proximal tubule it does not appear to act on the distal tubule. Torsemide acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na /K /2Cr-carrier system. 

Yarwood et al. (33) investigated the influence of cooling rate, initial concentration of solute, and fill volume on physical form and chemical stability of sodium ethacrynate. The freezing protocol consisted of ramping from room temperature to -25 C over four hours vs. placing vials on shelves... 

Yarwood RJ, Phillips AJ, Collett JH. Processing factors influencing the stability of freeze-dried sodium ethacrynate. Drug Dev Indust Pharm 1986 12 2157-2170. 

Pathophysiology Non-potassium-sparing diuretics are the treatment of choice to reduce fluid retention and dyspnea. Acting at specific sites of nephrons, they inhibit sodium and water reabsorption. Loop diuretics act on the loop of Henle, producing a maximal diuretic effect equivalent to 20% to 25% of the filtered sodium load and promoting the free water clearance. Currently available loop diuretics include furosemide, bumetanide, torsemide, and ethacrynic acid. Because of their potency, they are generally effective in patients with advanced renal insufficiency (glomerular filtration rates <25 ml/min) (49). 

Dopamine is degraded by alkaline preparation and is incompatible with sodium bicarbonate solutions, furosemide, ampicillin, amphotericin, gentamicin sulfate, cephalothin sodium, oxacillin sodium, and thiopentone sodium. Percussion or excessive heat may cause an explosion with undiluted erythrityl tetranitrate. Care must be exercised to avoid contact with skin, eyes, and mucous membranes when handling ethacrynic acid. Sodium ethacrynate solutions are incompatible and less stable at very high pH, below pH 5, and at higher temperatures. 

High-ceiling loop diuretics. Diuretics that cause a substantial diuresis, up to 20% of the filtered load of NaCl and water. Loop diuretics, such as furosemide, inhibit the re-absorbtion of sodium at the ascending loop, which leads to a retention of water in the urine. Other examples of high-ceihng loop diuretics include ethacrynic acid, torsemide and bumetanide. 

Synonyms. Etacrynate Sodium Sodium Etacrynate Sodium Ethacrynate. Proprietary Names. Edecrin(e) (injection) Hydromedin (injection). C,3H,Cl2Na04 = 325.1 CAS—6500-81-8... 

High-melting point crystalline salts will generally be the most stable, in contrast to amorphous or liquid/oil salt forms. Thus amorphous ethacrynic acid and amorphous sodium ethnacrynate are less stable than the crystalline forms. ... 

Yarwood, R.J. Philhps, A.J. Collett, J.H. The influence of freeze drying on the stability and dissolution of sodium ethacrynate. J. Pharm. Pharmacol. 1983, 55, P4. 

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