Central nervous system disturbances

Mode of Motion. The cyclodienes, like lindane and toxaphene, affect the nerve axon produciag hyperactivity, convulsions, prostration, and death. The biochemical lesion is the competitive inhibition of the y-aminobutyric acid (GABA) neurotransmitter binding site of the nerve axon. Spray workers with lengthy exposure to dieldrin have suffered from prolonged and repeated central nervous system disturbances produciag epileptiform coavulsioas. Similar disturbances occurred ia workers heavily exposed to chlordecoae. 

HE is a central nervous system disturbance with a wide range of neuropsychiatric symptoms associated with hepatic insufficiency and liver failure. 

Cu deficit, excess of Mo and SO Pre-Caucasian plain, Caspian low plain, West Siberian Steppe ecosystems Meadow-Steppe, Eustric Chernozems, Solonchaks, Arenosols The reducing Cu content in the central nervous systems, depressed function of oxidation ferments and activation of catalase, demielinization of the central nervous systems, disturbance of motion, convulsions. Endemic ataxia. Lamb disease is predominant... 

Cataldo, A.M., Hamilton, D.J., Barnett, J.L., Paskevich, P.A., and Nixon, R.A., 1996, Properties of the endosomal-lysosomal system in the human central nervous system disturbances mark most neurons in populations at risk to degenerate in Alzheimer s disease. J. Neurosci. 16 186-199... 

In rats, 40% propene caused light anesthesia with no other toxic symptoms within 6 hours 55% propene for 3-6 minutes or 70% propene for 1-3 minutes produced deep anesthesia with no additional central nervous system disturbances. Animal experiments with cats have shown no toxic signs when anesthesia was induced at concentrations of 20-31% however, 70% propene resulted in a drop in blood pressure and an increased pulse rate, and an unusual ventricular ectopic beat occurred at concentrations ranging from 50% to 80%. 

Trimethoprim produces the predictable adverse effects of an antifolate drug, especially megaloblastic anemia, leukopenia, and granulocytopenia. The combination trimethoprim-sulfamethoxazole may cause all of the untoward reactions associated with sulfonamides. Nausea and vomiting, drug fever, vasculitis, renal damage, and central nervous system disturbances occasionally occur also. Patients with AIDS and pneumocystis pneumonia have a particularly high frequency of untoward reactions to trimethoprim-sulfamethoxazole, especially fever, rashes, leukopenia, diarrhea, elevations of hepatic aminotransferases, hyperkalemia, and hyponatremia. 

The major side-effects of indomethacin are gastrointestinal and central nervous system disturbances such as depression, drowsiness, tinnitus and convulsions. 

Accordingly, increased central nervous system disturbances (e g., depression) may be expected following concurrent exposure to benzene and ethanol. 

Geiderman JM. Central nervous system disturbances following clarithromycin ingestion. Clin Infect Dis 1999 29(2) 464-5. 

SAFETY PROFILE Poison by intravenous route. Moderately toxic by ingestion and skin contact. Human systemic effects coma, convulsions, dermatitis, mydriasis (pupiUar dilation), nausea or vomiting, stiffness. An eye and skin irritant. Experimental reproductive effects by skin contact. Mutation data reported. Can cause central nervous system disturbances. A pesticide. DEET is the active ingredient in most commercial insect repellents. When heated to decomposition it emits toxic fumes of NO,. 

An insecticide. Ingestion can cause damage to eyes, nausea, vomiting, diarrhea, and central nervous system disturbances. An FDA proprietary drug. Used as a miotic agent. When heated to decomposition it emits toxic fumes of F and POx. See also PARATHION. 

Adverse reactions include gastrointestinal upset, rashes, photosensitivity, headache, and also various central nervous system disturbances. 

Adverse effects of this partial agonist include nausea, vomiting, dizziness, sweating, hypertension, palpitations, tachycardia, central nervous system disturbance (euphoria, dysphoria, psychotonumesis). 

Central nervous system disturbances, especially impaired cerebellar function, limit doses of cytarabine, and age is an important predictive factor. Of 418 patients who received 36-48 g/m only 35 (8%) had severe cerebellar toxicity, which was irreversible or fatal in 4 (1%) (2). Patients over 50 years of age were significantly more likely to develop cerebellar problems than younger patients (26/137, 19%, compared with 9/281, 3%) a second course did not increase the incidence, implying that it is the individual rather than the cumulative dose that is important. 

In an open comparison of efavirenz and indinavir (plus two nucleoside analogues) in predominantly treatment-naive patients efavirenz-based triple therapy provided at least similar antiviral effects over 48 weeks (7). Furthermore, fewer patients discontinued efavirenz-based triple therapy than indinavir-based therapy because of adverse events. Adverse effects associated with efavirenz included a maculopapular rash and central nervous system disturbances (dizziness, vivid dreams, poor concentration, sleep disturbances), which generally occurred (but later resolved) within the first weeks of therapy. 

Topical miconazole is well tolerated. Parenteral administration carries a higher frequency of adverse effects, some probably being caused by Cremophor (polyethoxylated castor oil, the carrier). Adverse effects include fever, chills, pruritus, rash, nausea, vomiting, diarrhea, hjrpona-tremia, cardiac toxicity, phlebitis, hyperhpidemia, and central nervous system disturbances. Hypersensitivity reactions can occur. Tumor-inducing effects have not been reported. 

Like many organic compounds, excessive acute exposure to dibenz[d, /i]anthracene can lead to dizziness, nausea, and general central nervous system disturbances that resemble intoxication. Previous exposure to polyaromatic hydrocarbons or genetic predisposition can increase the MFO system that activates dibenz[d, /i]anthracene to the reactive epoxide. In addition, personal habits such as smoking can significantly increase a person s exposure to these compounds. 

NOTE If automatic injectors are used in the absence of exposure to agent, the following signs and symptoms may be seen Dry mouth, dry skin, fast pulse (>90 beats per minute), dilated pupils, retention of urine and central nervous system disturbance. Susceptibility to heat exhaustion or heat stroke is increased with ambient temperatures above 85°F, particularly in closed spaces or while wearing protective clothing, or while conducting any activity. 

ACUTE HEALTH RISKS irritation of eyes, skin and respiratory system drowsiness hallucinations confusion fatigue central nervous system disturbances incoordination peripheral neuropathy. 

CHRONIC HEALTH RISKS central nervous system disturbances paresthesia blurred vision speech difficulties deafness malaise (vague feeling of discomfort) constriction of the visual field permanent damage to the brain mental retardation and cerebral palsy in infants significant developmental defects severe dermatitis skin sensitization has occurred. 

CHRONIC HEALTH RISKS central nervous system disturbances target organs blood, liver, kidneys, cardiovascular system, male reproductive system, spleen. 

Weiss GB, Weiden PL, Thomas ED. Central nervous system disturbances after combined administration of procarbazine and mechlorethamine. Cancer Treat Rep (1977) 61, 1713-14,... 

Eating raw ginkgo seed may cause toxic reactions such as nausea, vomiting, seizures, and other symptoms of central nervous system disturbances (Chen and Chen 2004 Leung and Foster 1996), and even cooked seed should be eaten only in small amounts (Leung and Foster 1996). These concerns are not associated with the seed administered in decoction (Bensky et al. 2004). 

Other symptoms of overdose of ginkgo seed may include abdominal pain, dyspnea, and other symptoms related to central nervous system disturbances (Bensky et al. 2004 Chen and Chen 2004). The compound 4 -0-methylpyridoxine, a neurotoxin that can cause vitamin B5 deficiency symptoms, is believed to be responsible for the toxic effects of ginkgo seed (Wada et al. 1985). Although... 

Yamazaki, J. N. A Review of the Literature of the Radiation Dosage Required to Cause Manifest Central Nervous System Disturbance from in Utero and Postnatal Exposure. Pediatrics 36, no. 5, pt. 2, suppl. (May 1966). 

CYP2B6516G>T polymorphisms significantly affect the metabolism of efavirenz. In 63 HIV-infected children, median age 12 (range 3-19) years, who took efavirenz for at least 4 weeks, CYP2B6516 G/G, G/T, and T/T genotypes were found in 48%, 41%, and 11% respectively [148 ]. The516G>T allele frequency was 32%. The mean concentrations of efavirenz for children with the G/G, G/T, and T/T genotypes were 1604, 2635, and 11 582 ng/ml respectively. There was a correlation between efavirenz concentrations over 4000 ng/ml and psychiatric adverse effects, but no association with rashes, hepatotoxic-ity, or central nervous system disturbances. 

Central nervous system disturbances. It assists in energy transformation in brain and nerve tissue hence, the functioning of the central nervous system. When vitamin B-6 is lacking, convulsive seizures occur in both human infants and experimental animals. 

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