Protein kinase Localization

Helps NR, Luo X, Barker HM et al (2000) NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centro-somes, is complexed to protein phosphatase 1. Biochem J 349 509-518... 

Kakita M, Murase K, Iwano M, Matsumoto T, Watanabe M, Shiba H, Isogai A, Takayama S. 2007. Two distinct forms of M-locus protein kinase localize to the plasma membrane and interact directly with S-locus receptor kinase to transduce selfincompatibility signaling in Brassica rapa. Plant Cell 19(12) 3961-3973. 

Tasken K, Aandahl EM (2004) Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev 84 137-167... 

The growth requirement for EGF is a good example in this regard. EGF stimulates the growth of many different types of animal cells in culture. In order to initiate the growth response, EGF interacts with specific EGF receptors localized in the plasma membrane, activating a tyrosine-specific protein kinase, which is an intrinsic part of the receptor (Figure 12). As a consequence, specific proteins are phosphorylated at tyrosine residues, and some of these proteins (which are also... 

Booher, R., and Beach, D. (1986). Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccaromyces pombe. Mol. Cell. Biol. 6 3523-3530. Booher, R. N., Alfa, C. E., Hyams, J. S., and Beach, D. H. (1989). The fission yeast cdc2/cdcl3/sucl protein kinase regulation of catalytic activity and nuclear localization. CeU 58 485-497. 

Mochly-Rosen, D. Localization of protein kinases by anchoring proteins A theme in signal transduction. Science 268 247-251,1995. 

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