Cellular gene products

Chuang, S.E., Cheng, A.L., Lin, J.K., and Kuo, M.L., Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats, Foorf Client. Toxicol, 38 (11) 991-995,2000. 

Katze, M. G., Persson, H., and Phillipson, L., 1981, Control of adenovirus gene expression Post-transcriptional control mediated by both viral and cellular gene products. Mol. Cell. Biol. 1 807. 

Underwood M, Harvey R, Stanat S, Hemphill M, Miller T, Drach J, Townsend L, Biron K (1998) Inhibition of human cytomegalovirus DNA maturation by a benzimidazole ribonucleoside is mediated through the UL89 gene product. J Virol 72 717-725 Van Maele B, Debyser Z (2005) HlV-1 integration an interplay between HIV-1 integrase, cellular, and viral proteins. AIDS Rev 7 26 3... 

Nocka, K., Majumder, S., Chabot, B., Ray, P., Cervone, M., Bernstein, A., and Besmer, P. (1989). Expression of the c-kit gene products in known cellular targets of W mutant mice-evidence for an impaired c-kit kinase in mutant mice. Genes Dev. 3 816-826. 

The immediate early gene product c-Fos (cellular feline osteosarcoma) has widely been used as a useful marker of neuronal activation. Fos, the protein encoded by the c-fos gene, is a transcription factor that triggers transcription in a cascade of cellular responses. To determine which neuron groups are involved in the response to PGD2 and/or adenosine, especially A2aR agonists, we examined Fos-immunoreactivity under these conditions (Scammell et al., 1998, 2001 Satoh et al., 1999). 

H., Gottesman, M. M., Pastan, I., Willingham, M. C., Cellular localisation of the multidrug resistance gene product P-glycoprotein in normal human tissues, Proc. Natl. Acad. Sci. USA 1987, 84, 7735-7738. 

Association studies are used to identify common alleles more frequently associated with phenotypic traits such as drug response or ADRs. These associated alleles are called causal polymorphisms or functional polymorphisms and are risk-conferring factors of the trait at the population level, while, at the individual level, they impact either on the cellular level of the gene product or its function. 

Thiebaut F, Tsumo T, Hamada H, Got-tesman MM, Pastan I, Willingham MC. Cellular localization of the multidrug resistance gene product in normal human tissues. Proc Natl Acad Sci USA 1987 84 7735-7738. 

Coschigano, P. W., and Magasanik, B. (1991). The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione S-transferases. Mol. Cell. Biol. 11, 822-832. 

As with c-erbB, overexpression of the suppressor p53 gene product has been found in different cancers (H3). Initially, it was believed that the detection of p53 protein in tumors meant the presence of a mutant gene product. However, we now know that normal p53 protein can be overexpressed in response to certain stimuli and stabilized by interaction with both cellular and viral proteins (H3). Irrespective of the mechanism giving rise to elevated protein levels, overexpression of p53 has been shown to be a prognostic marker in both breast and colorectal cancers (D8). In some studies, the presence of high levels of p53 has been shown to be a prognostic marker in axillary node-negative breast cancer patients (H3). 

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