Cancer cell lines inhibition

The present work seeks to compile information about the cancer cell lines inhibited by different groups of natural and synthetic flavonoids reported in the literature and try to find and discuss structural requirements implicated in the activity to obtain a working hypothesis to help to rationalize the development of flavonoids as antitumor compounds. 

Table 1. Cancer Cell Lines Inhibited by Flavones. 

Krystal, G.W. et al., Lck associates with and is activated by Kit in a small cell lung cancer cell line inhibition of SCF-mediated growth by the Sre family kinase inhibitor PPl, Cancer Res., 58,4660,1998. 

The RXR-RXR antagonist LDG100754 and RAR-selective TTNPB activated RXR-RAR heterodimers on DR-2 and DR-5 RAREs, whereas LDG100268 did not however, only TTNPB dissociated the corepressor SMRT from the RXR-RAR complex [36]. The synergy between RXR-selective retinoids and RAR-selective retinoids was ably demonstrated by Wu et al. [105]. RXR-selective SRI 1345 at 1.0 pM, which only inhibited MDA-MB-231 breast cancer cell growth by less than 5%, enhanced the inhibitory activity of RAR-selective SRI 1365 from below 5% to 55%. In the ZR-75-1 human breast cancer cell line, inhibition by SRI 1365 rose from 40% to 70%, after addition of SRI 1345, which alone was inactive. 

Barbieri and coworkers have studied the antiproliferative activity and interactions of cell-cycle-related proteins utilizing the organotin compoimd containing a quinolizidine derivative. The particular compoimd studied was triethyltin lupinylsulfide hydrochloride (5). In early tests this compound was found to show good cancer cell line inhibition, so more extensive studies were undertaken. 

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