Ranitidine hydrochloride

Gitberow, Sawbridgeworth John Bradshaw, Ware, all of England 

N-[2-[[[5-(Dimethylamino)methyl-2-furanyl]methyl]thi-o]ethyI]-N -methyl-2-nitro-1,1-ethenediamine hydrochloride 

16 mole) was dissolved in industrial methylated spirit 74 o.p. (200 ml) containing 0.16 of an equivalent of hydrogen chloride. Ethyl acetate (200 ml) was added slowly to the solution. The hydrochloride crystallised and was filtered off, washed with a mixture of industrial methylated spirit 74 o.p. (50 ml) and ethyl acetate (50 ml) and was dried at 50. The product (50 g) was obtained as an off-white solid m.p. 133 I34.  

In October 1981, Glaxo filed a patent application on Form 2, from which two patents were eventually granted in June of 1985 as U.S. Patent No. 4,521,431 (the 431 patent) and June 1987 as U.S. Patent No. 4,672,133. The abstract of the 431 patent states simply, A novel form of ranitidine... hydrochloride, designated Form 2, and having favourable filtration and drying characteristics, is characterized by its infra-red 

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Ranitidine. Ranitidine hydrochloride [66357-59-3] (Zantac) is a white to pale yellow granular substance. It is freely soluble in water and acetic acid, soluble in methanol, sparingly soluble in ethanol, and practically insoluble in chloroform. It has a slightly bitter taste and a sulfur-fike odor. It may be made by the method described in Reference 5. 

Isolation cimetidine, famotidine, nizatidine, and ranitidine hydrochlorides... 

Secondary processing does not always lead to phase transformations, as was shown during studies of the polymorphs of ranitidine hydrochloride [92]. No solid-solid transformation could be detected during either the grinding or compression of metastable Form I, stable Form II, or of a 1 1 mixture of these forms. The dissolution rates of both forms were found to be equivalent, and the solution-mediated transformation of Form I to Form II was observed to be slow. 

Fig. 7.14. X-ray powder diffraction patterns of ranitidine hydrochloride, Form I (thick trace) and Form II (thin trace) [47].

Pantoprazole (Protonix) Rabeprazole (AcipHex) Ranitidine Hydrochloride (Zantac)... 

Chieng, N., Zujovic, Z., Bowmaker, G., Rades, T., and Saville, D. (2006). Effect of milling conditions on the solid-state conversion of ranitidine hydrochloride forrtnlt . J. Pharm. Sci., 327 36-44. 

Terahertz pulse spectroscopy was used to observe the polymorphs of ranitidine hydrochloride.91 Sample preparation for this technique is the same as for Raman and FTIR spectroscopy and the data generated is complementary to Raman. Terahertz pulse spectroscopy provides information on the low-frequency intermolecular modes that are difficult to study with Raman due to the proximity of the laser excitation line. The authors concluded that this technique has many applications in pharmaceutical science including formulation, screening and stability studies. 

Taday, P.F. Bradley, I.V. Arnone, D.D. etal., Using terahertz pulse spectroscopy to study the crystalline structure of a drug A case study of the polymorphs of ranitidine hydrochloride /. Pharm. Sci. 2003, 92, 831-838. 

Midazolam Hydrochloride Midazolam hydrochloride is incompatible with a number of drugs, and precipitation is observed, presumably due to a pH of 5 or more with dimenhydrinate, pentobarbitone sodium, perphenazine, frusemide, thiopentone, prochlorperazine edisylate, ranitidine hydrochloride, and various intravenous fluids.164 Solutions of midazolam hydrochloride should not be combined with Hartmann s solution, as the potency of midazolam may be affected.165... 

Infra-red Spectrum. Principal peaks at wavenumbers 1220,1620, 1192, 1570, 1590, 1260 (ranitidine hydrochloride, KBrdisk). 

Ranitidine Hydrochloride Prenylamine Lactate Profadol Hydrochloride... 

Fig.4.28 (a, b)IR spectra of (a) Form 1 and (b) Form 2 of ranitidine hydrochloride. The spectra are very similar (though not identical) in many respects, with one particularly distinguishing band at 1045 cm in the spectrum of Form 2. (From Cholerton et al. 1984, with permission.) Detail of the (c) Form 1 and (d) Form 2 FTIR spectra of the two polymorphs of ranitidine hydrochloride, including the instrument-determined location of individual peaks. (FromForster et al. 1998, with permission.)... 

Fig. 4.41 SEM images of the two forms of ranitidine hydrochloride. Upper, Form 1 lower, Form 2. (Courtesy of Glaxo SmithKline.)...

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