Suppositories containers

Miconazole nitrate vaginal suppositories contain not less than 90% and not more than 110%i of the labeled amount of C18H14CI4N2O HNO3. 

If 12 cocoa butter suppositories containing 40% zinc oxide weigh 17.6 grams, what is the displacement value of zinc oxide Assume that the suppositories are made in a 1-g mold. 

What would be the displacement value of hydrocortisone acetate if it is known that ten suppositories containing 250 mg each of the drug weigh 20.83 g ... 

Twelve phenobarbital sodium suppositories containing 60 mg of drug each weigh 24 g. The mold of suppository used was 2 g. 

Show how you would prepare 15 prochlorperazine suppositories containing 30 mg of the drug in each suppository. Assume that you are required to use cocoa butter and that the displacement value of prochlorperazine is 2. 

Rectal administration For outpatient treatment when oral dosing is not possible, suppositories containing 25 mg metoclopramide have been extemporaneously compounded (5 pulverized oral tablets in polyethylene glycol). Administer 1 suppository 30 to 60 minutes before each meal and at bedtime. 

Vaginal cream contains mineral oil and vaginal suppositories contain an oleaginous base which may weaken rubber or latex products such as condoms, avoid use within 72 hr following treatment with vaginal cream or suppositories... 

Takatori T, Yamamoto K, Yamaguchi T, Higaki K, Kimura T. Design of controlled -release morphine suppositories containing polyglycerol ester of fatty acid. Biol Pharm Bull 2005 28(8) 1480-1484. 

Choi HK, Oh YK, Kim CK. In-situ gelling and mucoadhesive liquid suppository containing acetaminophen enhanced bioavailability. Int J Pharm 1998 165 23-32. 

Lindmark, T., et al. 1997. Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate. Pharm Res 14 930. 

Hosny, E.A., H.I. Al-Shora, and M.M. Elmazar. 2001. Effect of different bile salts on the relative hypoglycemia of witepsol W35 suppositories containing insulin in diabetic beagle dogs. Drug Dev Ind Pharm 27 837. 

An important issue that has been recognized recently concerns the potential adverse effect of absorption enhancers on the rectal mucosa, as shown in rats after a single application [61,62], Safety evaluation of the applicability of absorption enhancers is imperative. In clinical application, medium-chain fatty acids such as sodium caprate are used only for suppositories containing antibiotics [36],... 

Watanabe, Y., et al. 1992. Absorption enhancement of polypeptide drugs by cyclodextrins. I. Enhanced rectal absorption of insulin from hollow-type suppositories containing insulin and cyclodextrins in rabbits. Chem Pharm Bull 40 3042. 

Watanabe, Y., et al. 1998. Studies of drug delivery systems for a therapeutic agent used in osteoporosis. I. Pharmacodynamics (hypocalcemic effect) of elcatonin in rabbits following rectal administration of hollow-type suppositories containing elcatonin. Biol Pharm Bull 21 1187. 

FIGURE 8.2 Serum levels of 4-biphenylacetic acid (BPAA) after rectal administrations of Witepsol H-5 suppositories containing BPAA or its CyD complexes to rats. Each point represents the mean of five rats. p < 0.05, compared with BPAA alone. 

FIGURE 8.3 Bioavailability of morphine after rectal administrations of Witepsol H-15 hollow-type suppositories containing morphine hydrochloride (MH) and CyDs in rabbits. Each value represents the mean SE of three rabbits. p < 0.05, compared with MH alone. 

CyDs are known to be able to solubilize lipophilic drugs as well as lipophilic absorption enhancers, leading to the improvement of the enhancer s efficiency. There are some reports on the use of CyDs as a candidate for a coenhancer. For example, Yanagi et al. [35] reported that CyDs may promote the potency of absorption enhancers in rectum of rabbits. Inclusion complex of decanoic acid (CIO), an absorption enhancer, with a-CyD was prepared as an additive of cefmetazole sodium suppository and rectally administered to rabbits. Plasma concentration and area under the curve (AUC) of cefmetazole sodium after rectal administration of a suppository containing ClO-a-CyD complex to rabbits increased more significantly than those with no additive. 

Szente, L., et al. 1985. Suppositories containing cyclodextrin complexes. Part 2 Dissolution and absorption studies. Pharmazie 40 406. 

Iwaoku, R., et al. 1982. Enhanced absorption of phenobarbital from suppositories containing phenobarbital-(3-cyclodextrin inclusion complex. Chem Pharm Bull 30 1416. 

Hosny, E.A. 1999. Relative hypoglycemia of rectal insulin suppositories containing deoxycholic acid, sodium taurocholate, polycarbophil, and their combinations in diabetic rabbits. Drug Dev Ind... 

Nakajima, T., et al. 1990. Indomethacin sustained-release suppositories containing sugar ester in polyethylene glycol base. Chem Pharm Bull 38 1680. 

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