Carcinogenicity potential

The element and its compounds are toxic and should be handled carefully. Contact of the metal with skin is dangerous, and when melting the metal adequate ventilation should be provided. Exposure to thallium (soluble compounds) - skin, as Tl, should not exceed 0.1 mg/ms (8-hour time-weighted average - 40-hour work week). Thallium is suspected of carcinogenic potential for... 

A comprehensive search (295) of the STORET water quaUty database, maintained by the U.S. EPA Office of Water, is used to evaluate the potential water quaUty implications of various herbicides. This database contains information on contamination of surface water (SW) and groundwater (GW) suppUes. The data are provided to give a general impression of the occurrence of a given herbicide in SW and GW (269). The U.S. EPA scheme for categorizing a chemical s carcinogenic potential is used for herbicides for which healthy advisory information (HA) is available. The U.S. EPA is continually issuing HAs for various environmental contaminants HAs available in Reference 269 were used in preparation of this article. 

Considerable concern has been raised over the carcinogenic potential of 2,4-D. However, the World Health Organization (WHO) has evaluated the environmental health aspects of this chemical and concluded that 2,4-D posed an insignificant threat to the environment. They did indicate, however, that... 

U.S. Environmental Protection Agency, Eist of Chemicals Evaluatedfor Carcinogenic Potential, internal memorandum, EPA, Washington, D.C., Feb. 1992. 

A further consensus developed within the scientific community regarding the relative carcinogenicity of the different types of asbestos fibers. There is strong evidence that the genotoxic and carcinogenic potentials of asbestos fibers are not identical in particular mesothelial cancer is mostiy, if not exclusively, associated with amphibole fibers (43). 

A. Barter and R. S. Nair, Review of the S cientific Evidence on the Human Carcinogenic Potential ofPara-Dichloroben iene, Chlorobenzene Producers Association, Washington, D.C., 1990. 

The property most frequently cited in connection with the use of Ti dental or medical appHances is titanium s unique biocompatibiHty. This helps practitioners avoid occasional allergic reactions that occur with nickel or chromium alloys, and removes concerns about the toxic or carcinogenic potential of appHances that contain nickel, chromium, or beryUium. Wrought alloys of titanium are used for orthodontic wires because of their unique elastic... 

A1 - Confirmed Human Carcinogens. Substances, or substances associated with industrial process, recognized to have carcinogenic potential. 

Gielen, M. Willem, R. In Hadjiliadis, N. D. (Ed.), Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment, NATO ASI Series 2 Environment, Kluwer Academic, Dordrecht, 1997 Vol. 26, p. 445. 

The carcinogenic potential of the profiled substance is qualitatively evaluated, when appropriate, using existing toxicokinetic, genotoxic, and carcinogenic data. ATSDR does not currently assess cancer potency or perform cancer risk assessments. Minimal risk levels (MRLs) for noncancer end points (if derived) and the end points from which they were derived are indicated and discussed. 

A1 — Confirmed Human Carcinogens. Substances, or substances associated with industrial processes, recognized to have carcinogenic potential. A2 - Suspected human carcinogens. Chemical substances, or substances associated with industrial processes, which are suspect of inducing cancer, based on either limited epidemiological evidence or demonstration of carcinogenesis in one or more animai species by appropriate methods. 

The FDA [51] has used the MDL QSAR software [19] to develop QSARs for the carcinogenic potential of pharmaceuticals and organic chemicals. These were validated using a test set of 108 compounds, with 72% correct prediction of carcinogens and 72% correct prediction of noncarcinogens. 

Contrera JF, Matthews EJ, Benz RD. Predicting the carcinogenic potential of pharmaceuticals in rodents using molecular structural similarity and E-state indices. Regul Toxicol Pharmacol 2003 38 243-59. 

Woo Y-T, Lai DY, Argus ME, Arcos JC. Development of structure-activity relationship rules for predicting carcinogenic potential of chemicals. Toxicol Lett 1995 79 219-28. 

Because of its carcinogenic potential, the EPA-recommended concentration for trichloroethylene in ambient water is zero. However, because attainment of this level may not be possible, levels that correspond to upper-bound incremental lifetime cancer risks of 10, lO , and 10 are estimated. 

The DBPCAN database contains predicted estimates of carcinogenic potential for 209 chemicals detected in finished drinking water samples having undergone water disinfection treatment. 

No information on the carcinogenic potential of polyalphaolefin hydraulic fluids was located. Studies designed to assess carcinogenicity in animals exposed via inhalation, oral, and dermal routes or a well-controlled cohort retrospective or prospective study would be useful for determining the carcinogenic potential of polyalphaolefin hydraulic fluids. 

Casto BC, Meyers J, DiPaolo JA. 1979. Enhancement of viral transformation for evaluation of the carcinogenic potential of inorganic metal salts. Cancer Res 39 193-198. 

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