Risk extrapolation, estimating potential risks carcinogens

The use of the terms upper bound and worst-case refer to the expectations that this approach is likely to be highly conservative and will not underestimate potential risk. These terms are not meant to connote that statistical analysis to estimate error bounds would be performed, or that additional safety factors (traditional for extrapolation to acceptable daily intake values for non-carcinogens) would be incorporated into the extrapolation. 

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