Parathion carcinogenic potential

Chronic toxicity of organophosphates may be discussed under four different areas carcinogenicity, delayed neurotoxicity, experimental myopathy, and, in humans, psychiatric disorders. In 1983, the IARC (International Agency for Research on Cancer) evaluated the carcinogenic potential of, among other pesticides, five organophosphate insecticides/acaricides (malathion, methyl parathion, parathion,... 

Parathion ethyl 2-32 Rat, 2-year diet, NOAEL 2-mg/kg diet doses of 10-25 mg/kg. At doses of 10 and 25 mg/kg, no effect was observed. Higher doses show damage in retin and ciatic nerve. Classified in US as a potential carcinogen. Positive damage in DNA. 1.3-12.4 0.0178-2.7 0.07-7 Insecticide, acaricide... 

Aliphatic and aromatic nitro compounds are reduced at relatively positive potentials via the hydroxylamines to the corresponding amines. The carcinogenic 4-nitroquinoline-/V-oxide is determined by DPP in the presence of 4-hydroxyam-inoquinoline-/V-oxide and 4-aminoquinoline-/V-oxide via the reduction of the nitro group [79]. Nitrazepam, parathion, nitrofurantoin, and the ni-troimidazoles in blood plasma or urine are also determined via the reduction of the respective nitro groups. 

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