Carcinogenesis and

Symposium on Toxicology, Carcinogenesis, and Human Health Effects of 1,3-Butadiene (265). Detailed comparisons of various personal monitoring devices are available (266), and control of occupational exposure to 1,3-butadiene has been reviewed (267). ... 

Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Liebcrman, A. I. and Shmidt, J. L., Prevention of spontaneous and chemically-induecd earcinogenesis using activated earbon fiber adsorbent. I. Effeet of the aetivated carbon fiber adsorbent Aqualen on spontaneous carcinogenesis and life span in mice. Cancer Lett., 1998, 126(1), 23 28. 

A scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains some 8,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primaiy journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis. 

Farr CH, Reinisch K, Helsen JF, Neubert D (2001) Petential teratogenicity of di-n-butyltin dichloride and ether dibutyltin compounds. Teratogenesis, Carcinogenesis, and Mutagenesis, 21(6) 405-415. 

NAKAMURA s (1992) Fundamental study on influence of rice bran saccharide on ENNG carcinogenesis and immunocompetence of rat J Jap Soc for Cancer Theropy, 27(1) 13-20. 

Floyd, R.A. (1990). Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 4, 2587-2597. 

Brcimer, L.H. (1990). Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis. The role of DNA base damage. Mol. Carcinogen. 3, 188-197. 

LaFuma J, Nenot JC, Morin M, et al. 1974. Respiratory carcinogenesis in rats after inhalation of radioactive aerosols of actinides and lanthanides in various physicochemical forms. In Karbe E, Park JF, eds. Experimental lung cancer Carcinogenesis and bioassays, international symposium. New York Springer, 443-453. 

Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency - Emilia Romagna Region, Viale Filopanti 20, 40126 Bologna, Italy... 

Several chemicals can act as initiators and/or promoting agents participating actively in the process of carcinogenesis and also producing synergistic effects when taken simultaneously via multiple routes of exposure. 

Compared to animal assays, CTA is faster and cheaper. In vitro CTAs have been shown to involve a multistage process that closely resembles some stages of in vivo carcinogenesis and have the potential to detect both genotoxic and non-genotoxic carcinogens. 

Schrader T J, Cherry W, Soper K, Langlois I and Vijay H M (2001), Examination of Altemaria altemata mutagenicity and effects of nitrosylation using the Ames Salmonella Test , Teratogenesis, Carcinogenesis, and Mutagenesis, 21, 261-274. 

Department of Experimental Carcinogenesis and Metabolism, Hoffmann-La Roche, Inc., Nutley, NJ 07110... 

So we are still left with two models of the stereochemistry of DNA alkylated by a PAH diol epoxide the PAH either lies in a groove of DNA or else tries to intercalate between the bass of DNA. Since it is covalently bonded to a base it must cause considerable distortion if it tries to lie between the bases. However, the stacking observed in the crystalline state seems to argue for partial intercalation. We will need crystal structures of at least one appropriately alkylated polynucleotide before this problem can be resolved. And when this is done it will be just the beginning of the answer to the problem of alkylation of DNA by activated carcinogens. The subsequent question is, what is the lesion in DNA that is important in carcinogenesis, and then what does it cause to happen so that tumor formation is initiated ... 

In "Polynuclear Aromatic Hydrocarbons. Third International Symposium on Chemistry and Biology—Carcinogenesis and Mutagenesis" Ann Arbor Science Publishers Ann Arbor, Mich.,... 

These findings indicate that PGH synthase in the presence of arachidonate can catalyze the terminal activation step in BP carcinogenesis and that the reaction may be general for dihydrodiol metabolites of polycyclic hydrocarbons. Guthrie et. al. have shown that PGH synthase catalyzes the activation of chrysene and benzanthracene dihydrodiols to potent mutagens (33). As in the case with BP, only the dihydrodiol that is a precursor to bay region diol epoxides is activated. We have recently shown that 3,4-dihydroxy-3,4-dihydro-benzo(a)anthracene is oxidized by PGH synthase to tetrahydrotetraols derived from the anti-diol epoxide (Equation 4) (34). 

Garcia-Solis P, Yahia EM and Aceves C. 2008. Study of the effect of Ataulfo mango (Mangifera indica L) intake on mammary carcinogenesis and antioxidant capacity in plasma of /V-methyl-nitrosourea (MNU)-treated rats. Food Chem 111 309—315. 

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