Mutagenesis and Carcinogenesis

A scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains some 8,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primaiy journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis. 

Farr CH, Reinisch K, Helsen JF, Neubert D (2001) Petential teratogenicity of di-n-butyltin dichloride and ether dibutyltin compounds. Teratogenesis, Carcinogenesis, and Mutagenesis, 21(6) 405-415. 

Brcimer, L.H. (1990). Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis. The role of DNA base damage. Mol. Carcinogen. 3, 188-197. 

Schrader T J, Cherry W, Soper K, Langlois I and Vijay H M (2001), Examination of Altemaria altemata mutagenicity and effects of nitrosylation using the Ames Salmonella Test , Teratogenesis, Carcinogenesis, and Mutagenesis, 21, 261-274. 

In "Polynuclear Aromatic Hydrocarbons. Third International Symposium on Chemistry and Biology—Carcinogenesis and Mutagenesis" Ann Arbor Science Publishers Ann Arbor, Mich.,... 

Beland, F.A. and Kadlubar, F.F. (1990). Metabolic activation and DNA adducts of aromatic amines and nitroaromatic hydrocarbons. In Chemical Carcinogenesis and Mutagenesis, Cooper, C.S. and Grover, P.L. (eds), p. 267. Springer Verlag, Secaucus... 

Simmon VF. 1978. Structural correlations of carcinogenic and mutagenic alkyl halides. In Proceedings of the second FDA Office of Science Summer Symposium on Structural Correlates of Carcinogenesis and Mutagenesis, U.S. Naval Academy, August 31-September 2, 1977, 163-171. 

Means, J.C., Hassett, J.J., Wood, S.G., and Banwart, W.L. Sorption properties of energy-related pollutants and sediments, in Polynuclear Aromatic Hydrocarbons, Third International Symposium on Chemistry, Biology, Carcinogenesis and Mutagenesis, Jones, P.W. and Leber, P., Eds. (Ann Arbor, Ml Ann Arbor Science Publishers, 1979), pp. 327-340. 

Figure 1. A toxicological paradigm of environmental carcinogenesis and mutagenesis...

Barrett, J.C. and Elmore. E. (1984). Comparison of carcinogenesis and mutagenesis of mammalian cells in culture, in Handbook of Experimental Pharmacology, ANDREWS, L.S., Lorentzen, R.J., AND Flamm, W.D., Eds. (Springer-Verlag, Berlin). 

Cooper CS, Grover PL, eds. Chemical Carcinogenesis and Mutagenesis II. Handbook of Experimental Pharmacology. Vol. 94. Berlin Springer, 1990. 

Infante, P.F., Wagoner, J.K. Young, R.J. (1977) Chloroprene observations of carcinogenesis and mutagenesis. In Hiatt, H.H., Watson, J.D. Winsten, J.A., eds, Origins of Human Cancer, Book A, Cold Spring Harbor, NY, Cold Spring Harbor Laboratory, pp. 205-217... 

Asher, I.M. Zervos, C.. eds. Structural Correlates of Carcinogenesis and Mutagenesis,... 

Chlorogenic and caffeic acids may play a role in the body s defense against carcinogenesis and mutagenesis by their antioxidant properties. The antioxidant and antiradical influences of chlorogenic acids on lipid peroxidation are not yet clear. Research has indicated that chlorogenic acids are an antioxidant, however, their complex antioxidant properties require systematic investigation in diverse directions. 

Klopman, G. and Rosenkranz, H.S., Approaches to SAR in carcinogenesis and mutagenesis. Prediction of carcinogenicity/mutagenicity using MULTI-CASE, Mutation Res., 305, 33 -6, 1994. 

Laboratory of Environmental Carcinogenesis and Mutagenesis (Chief), NIEHS... 

H. Vainio and R. Saracci, in The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis (Eds. B. Singer and H. Bartch), IARC Scientific Publications, No. 70, Oxford University Press, New York, 1984, pp. 15-29. 

Keshava, C., Keshava, N., Whong, W.-Z., Nath, J. and Ong, T.-M. (1998) Inhibition of methotrexate-induced chromosomal damage by vanillin and chlorophyllin in V79 cells. Teratogenesis, Carcinogenesis, and Mutagenesis 1 7, 313-326. 

A number of short-term tests can be used to determine the genotoxic potential of chemicals. These tests use both prokaryotic and eukaryotic cells and measure such end points as gene mutations, chromosomal aberrations, and interactions with critical macromolecules It is widely recognized chat no test can detect all genotoxic compounds, and multiple end points are required to provide a reliable assessment of genotoxiclty. Information from several tests can be combined to reveal two important toxic effects carcinogenesis and mutagenesis. 

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