DIBUTYLTIN COMPOUND

The same dibutyltin compounds are used in the industrial manufacture of poly(urethane) foams, the first step in which involves the addition of a polyether glycol to 2,4-diisocyanotoluene, to produce the urethane prepolymer having isocyanate end-groups. 

Summer et al. (2003), in their review of the available data, refer to measured concentrations of mono- and dibutyltin compounds with maximum values of ... 

Farr CH, Reinisch K, Helsen JF, Neubert D (2001) Petential teratogenicity of di-n-butyltin dichloride and ether dibutyltin compounds. Teratogenesis, Carcinogenesis, and Mutagenesis, 21(6) 405-415. 

Effects of dibutyltin compounds on ATPase were investigated by Griffiths and co workers91,92. 

A problem of stannylene procedures, which has not yet found a uniformly satisfactory solution, is the disposal of the tin by-products, which are insoluble in water. In a few very favorabla cases, treatment with methanol converted them to the crystalline compound Br-BUjSn-O-SnBUj-OH, which could be removed by filtration. In the other cases, silica gel column chromatography is always successful. The highly lipophile, dibutyltin compounds move to the front in nonpolar eluents. However, chromatography is a great inconvenience in large-scale work. 

It should be noted that the cerebral edema produced by triethyltin can be regarded as a specific effect. However, the lesions of the bile ducts in rats and mice previously described for dibutyltin compounds appear to be a more species-specific effect. 

Gielen and Willem studied the in vitro cytotoxicity of diorganotin trimethoxy benzoates against 60 hiunan tumor cell Unes. In general, they found that the dibutyltin compounds were more active against human cancer cell lines than were die dietiiyltin derivatives. 

While most studies foimd that the dibutyltin derivatives are most active, some have reported other prescreening results. For instance, it was found that diethyltm and diphenyltin derivatives were more active during in vivo tests against P388 and L1210 murine leukemias in comparison to the dibutyltin compounds. ... 

The LD50 for dibutyltin acetate is 400 mg/kg. The LD50 for cisplatin is 12 mg/kg. By comparison, dibutyltin compounds appear to be less toxic dian cisplatin. ... 

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