DNA base damage

Brcimer, L.H. (1990). Molecular mechanisms of oxygen radical carcinogenesis and mutagenesis. The role of DNA base damage. Mol. Carcinogen. 3, 188-197. 

Dizdaroglu, M., Nackerdien, Z., Chao, B.C., Gajewski, E. and Rao, G. (1991b). Chemical nature of in vivo DNA base damage in hydrogen peroxide-treated mammalian cells. Arch. Biochem. Biophys. 285, 388-390. 

Kasprzak, K.S., Diwan, B.A., Rice, J.M., Misra, M., Riggs, C.W., Olinski, R and Dizdaroglu, M. (1992). Nickel(II)-mediated oxidative DNA base damage in renal and hepatic chromatin of pregnant rats and their fetuses. Possible relevance to carcinogenesis. Chem. Res. Tox. 5, 810-815. 

Measurement, chemistry, and biological importance of oxidative DNA base damage ... 

DNA base damage is also frequent after radiation (Ward, 1986). As compared to ssb, this DNA lesion is regarded as a possible source of mutation and is repaired through specific DNA repair pathways, such as base excision repair and nucleotide excision repair. 

Trewick, S.C., Henshaw, T.F., Hausinger, R.P., Lindahl, T. and Sedgwick, B. (2002) Oxidative demethylation hjEscherichia coli AlkB directly reverts DNA base damage. Nature, 419, 174-178. 

Kasprzak KS, Jaruga P, Zastawny TH, North SL, Riggs CW, Olinski R, Dizdaroglu M (1997) Oxidative DNA base damage and its repair in kidneys and livers of nickel(11)-treated male F344 rats. Carcinogenesis 18 271-277... 

The main types of damage that can be formed in DNA (base damage, apy-rimidnic/apurinic (AP) site, single-strand break (SSB), double-strand break (DSB), tandem lesions and various clustered lesions) are shown schematically in Fig. 12.1. There are, however, further lesions such as DNA/DNA and DNA/pro-tein cross-links. 

S. Senttirker, B. Karahalil, M. Inal, H. Yilmaz, H. Musliimanoglu, G. Gedikoglu, M. Diz-daroglu, Oxidative DNA base damage and antioxidant enzyme levels in childhood acute lymphoblastic leukemia. FEBS Lett. 416, 286-290 (1997)... 

Y. Wu et al., On the Mechanisms of OH- Radical Induced DNA-Base Damage A Comparative Quantum Chemical and Car-Parrinello Molecular Dynamics Study. J. Phys. Chem. A 108, 2922-2929 (2004)... 

Close to 100 products of DNA base damage caused by ROS have been identified (27), usually by treating bases, nucleosides. 

Cadet J, Delatour T, Douki T, Gasparutto D, Pouget JP, Ravanat JL, et al. Hydroxyl radicals and DNA base damage. Mutation Res. 1999 424 9-21. 

Bjelland S, Seeberg E. Mutagenicity, toxicity and repair of DNA base damage induced by oxidation. Mutation Res. 2003 531 37-80. 

Barnes DE, Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells.Annu.Rev. Genet. 

Douki T., Ravanat J.-L., Pouget J.-P, Testart I., Cadet J., Minor contribution of direct ionization to DNA base damage induced by heavy ions, Int. J. Radiat. Biol., 2006,82, 119-127. 

---