Membrane capillary

Glomerular filtration rate (GFR) is the volume of plasma-like fluid that is filtered per unit time across the glomerular capillary membranes to enter the tubular space. Filtrate formation is driven by the net filtration pressure that is equal to the capillary hydrostatic pressure diminished by the sum of capillary oncotic... 

Figure 13 presents a schematic diagram for drug absorption from the peritoneal cavity. As mentioned above, particles (e.g., erythrocytes, bacteria, colloidal gold, and liposomes) which are not able to pass capillary membranes are removed from the peritoneal cavity via the lymphatic system (Fig. 13, I and II). Relatively low molecular weight compounds (e.g., drugs) are exclusively absorbed via splenic blood capillaries into the portal vein (Fig. 13, III).

Flow inside the capillary membranes, depicted in the lower half of the plot and indicated by positive velocities, shows a regular pattern. The single capillaries are resolved, and flow inside each capillary possesses almost identical maximum velocities. Flow outside the membranes (upper half, negative velocities) reveals a different pattern. Flere, the different flow characteristics between the SMC and SPAN modules become distinct. Obviously, the capillaries in the SMC module are not packed in a regular manner. Large spaces in between the capillaries cause an irregular flow pattern in the dialysate-side with a maximum velocity of about -15 mm s-1 (Figure 4.6.2(a)), which is comparable to the maximum velocity in... 

The images obtained from the SPAN module (Figure 4.6.3(c and d)) show completely different characteristics compared with those from the SMC module. Noticeable features are the dense and evenly packed capillary membranes and the lower quality and inhomogeneities in the images. As already discussed for the ID profile (Figure 4.6.2(b)), both intra- and inter-membrane flow seems unhindered... 

FIGURE 10-5. Operative forces at the capillary membrane tending to move fluid either outward or inward through the capillary membrane. In hypovolemic shock, one therapeutic strategy is the administration of colloids that can sustain and/or draw fluid from the interstitial space by increasing the plasma colloid osmotic pressure. (Reprinted from Guyton AC, Hall JE. Textbook of Medical Physiology. 8th ed. Philadelphia Saunders,... 

Introduction of a water-soluble ionic substance into the vascular system results in an increase in the number of particles in the bloodstream as the contrast substance dissolves. The body possesses several internal regulation systems and, when perturbed by an injection, attempts to restore the concentrations of substances in the blood to their normal or preinjection levels. To re-equilibrate the system, water from the cells of surrounding body tissue moves into the blood plasma through capillary membranes. This transfer of water is an example of osmosis, the diffusion of a solvent (water) through a semipermeable membrane (the blood vessels) into a more concentrated solution (the blood) to equalize the concentrations on both sides of the membrane. To accommodate the increase in... 

The theoretical advantage of colloids is their prolonged intravascular retention time compared to crystalloid solutions. Isotonic crystalloid solutions have substantial interstitial distribution within minutes of IV administration, but colloids remain in the intravascular space for hours or days, depending on factors such as capillary permeability. However, even with intact capillary permeability, the colloid molecules eventually leak through capillary membranes. 

Many industrial yams have specific surface function requirements. For technical yams the market share for composites or coated fabrics is almost 70%. Furthermore, textile applications also can benefit from a special surface treatment in order to improve the water repellency. Capillary membranes for dialysis, however, have totally different requirements enhanced biocompatibility of the membranes is needed.4-6... 

Various membranes are in common use for the filtration of blood during dialysis. In this investigation cellulosic (Cuprophan) and synthetic (acryl nitrile, SPAN) capillary membranes were tested. The fluorine gas treatment was performed as described before. Three parameters are chosen for the assessment... 

Equilibrium dialysis of homogenates of kidneys of rats given mercuric chloride, revealed that over 99% of the mercury was not diffusible [40]. Diffusible compounds of mercury have the opportunity to cross the capillary membrane and enter the tissue spaces however, due to chemical affinities for cellular binding sites and the diffusible complex, and the ability to penetrate the cell membrane, not all diffusible complexes of mercury present in plasma lead to tissue accumulation. 

Fig. 1. Schematic illustration of a hepatocyte bioreactor with microcarrier-attachted hepatocytes. The capillary membranes are perfused with medium. (Modified from Dixit et al. [29])...

Several innovative membrane-based bioreactor designs have recently been proposed, including that by Sussman et al. [10], which involves the cultivation of hepatoma cells on the exterior surfaces of semipermeable capillary hollow fiber membranes which are bundled together with an enclosing plastic shell (Fig. 2). Required nutrient medium is circulated within the capillaries. After the hepa-tocytes have attached and formed a mass of liver tissue, the capillary membranes are perfused with the media. 

Since approximately 130 mL of plasma water is filtered across the porous glomerular capillary membranes each minute (190 L/day), the kidney is admirably suited for its role in drug excretion. As the ultrafiltrate is formed, any drug that is free in the plasma water, that is, not bound to plasma proteins or the formed elements in the blood (e.g., red blood cells), will be filtered as a result of the driving force provided by cardiac pumping. 

The alveolar-capillary membrane is normally very thin, has a huge surface area, and a large blood supply. Drugs given by this route, such as bronchodilators and pulmonary steroids, are rapidly absorbed into the bloodstream. This is also the route for administering the inhalational anaesthetics. DRUG METABOLISM AND EXCRETION... 

All inhaled anaesthetic drugs must be soluble in blood and brain in order to pass across the alveolar-capillary membrane and the blood-brain barrier. The term used to quantify solubility is partition coefficient. For anaesthetic purposes this is defined as the ratio of the concentration of dissolved gas/vapour in the blood to the concentration in the alveoli at... 

L. M. Pismen and A. J. Babchin, The electro-osmotic enhancement of the neutral tracer transfer through a capillary membrane, J. Coll. Interf. Sci., 62 (1977), pp. 63-68. 

By far, the most advanced technology in cnrrent nse is the hollow fiber techniqne. It has been reviewed extensively in the literature. Briefly, this configuration involves the cultivation of hepatocytes on the external surfaces of semipeimeable capillary hollow fiber membranes bundled together within a plastic shell. Nutrients and ultimately plasma from patient blood are circulated through the fibers. The cells in the capillaries provide hepatic function. In the current versions of this technology, cultured porcine hepatocytes are protected from the body s immune system by the semipermeable capillary membrane. 

Finally, gap spacing and pressurization are truly the heart of the problem. The desirable conditions are fineness of the spacer material, its water repellency, and the degree to which it maintains the air pressure excess over the entire membrane surface. Drifilmed talc powder, Xerox powder, and silicone-coated pumice powder have all been used with success with relatively low pressure differentials across the sea water capillary membrane. 

---