Bioreactors design

Alternatively, some subunit viral vaccines can be generated by rDNA techniques and expressed in a continuous ceU line or insect ceUs. Recent advances in bioreactor design and operation have improved the successful production of IPV in large-scale bioreactors. However, roUer bottles or flasks are stiU used for most current vaccine production. Development of insect ceU culture will allow for very large-scale Hquid suspension culture (143). Several vaccine candidates such as gpl60 for HIV and gD protein for herpes have been demonstrated in the insect ceU culture system. However, no vaccine has been approved for human use. 

McDuffie, N. G., Bioreactor Design Fundamentals, Butterworth/Heine-mann, Stoneham, Massachusetts, 1991. 

Biotechnology by Open Fearning, Bioreactor Design and Product Yield, Butterworth-Heinemann, ISBN 07506-15095, 1992. 

Bioreactor Design and Product Yield Product Recovery in Bioprocess Technology... 

The actual fermentation process is known as the incubation phase and is just part of the batch cycle. A complete fermentation cycle can typically include the following steps, most likely depending on bioreactor design ... 

A tubular bioreactor design with operational may lead to a CSTR, having sufficient recycle ratio for plug flow that behave like chemostat. The recirculation plug flow reactor is better than a chemostat, with maximum productivity at C, 3 g-m 3. Combination of plug flow with CSTR which behave like chemostat was obtained from the illustration minimised curve with maximum rate at CSf = 3 g-m-3. 

Tramper J, Joustra D, Vlak, JM (1987) Bioreactor design for growth of shear-sensitive insect ceU. In Webb C, Mavitima R (eds) Plant animal ceU ciUtiu es process possibUities. Ellis Horwood, England... 

BIOREACTOR DESIGN FOR SHEAR SENSITIVE CELL CULTURES... 

Reinhart, D.R. and Townsend, T.G., Landfill Bioreactor Design Operation, Lewis Publishers, Boca Raton, FL, 1998. 

The high sulfur-containing feedstock and the biocatalyst, usually suspended in the aqueous phase have to be contacted with each other in a bioreactor. A homogeneous, continuous phase would be preferred, which would imply formation of an emulsion, preferably a microemulsion. Several bioreactor designs have been suggested for biodesulfurization of petroleum feedstocks including impeller-mixed systems [65,202], electro-spray bioreactor [220,261,262], and draft tube air-lift bioreactor [263],... 

There are a wide variety of three-phase fluidized bioreactor designs possible. The conventional reactor, shown in Fig. 9, is fluidized by both gas and liquid entering at the bottom of the reactor and leaving at the top and is the most common type of three-phase fluidized bed bioreactor. This reactor may be configured to operate with little axial liquid mixing or in a well-mixed mode by adding a recycle stream. The airlift reactor or draft tube fluidized bed reactor, Fig. 10, is also frequently used. In this reactor, gas is injected at the bottom of a draft tube placed in the center of the... 

The present survey addresses studies on azo-dye conversion by means of bacteria, with a close focus on bioreactor design and operational strategies. Other chapters of the Handbook and recently published reviews [1, 2] address instead the detailed biochemical pathways underlying azo-dye conversion and the fate of the conversion products. 

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