Candida glabrata

Mehra RK, JR Garey, DR Winge (1990) Selective and tandem amplification of a member of the metallothionein gene family in Candida glabrata. J Biol Chem 265 6369-6375. 

O The predominant pathogen associated with vulvovaginal candidiasis is Candida albicans, although a small percentage of cases are caused by Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsilosis. 

Candida albicans accounts for 80% of cases of OPC and esophageal candidiasis. Over the last 20 years, an increasing incidence of C. albicans resistance has been accompanied by an increased incidence of non-albicans species infections, including Candida glabrata, Candida tropicalis, Candida krusei, and Candida parapsilosis. In patients with cancer, non-albicans Candida species account for almost half of all cases.29... 

Candesartan, molecular formula and structure, 5 152t Candida, 26 446 Candida albicans, 26 475 Candida antarctica lipase B, 70 307 Candida glabrata, genome of, 26 450t Candida utilis, 26 473 Candle filters, 77 362—363 Cando-luminescence, cerium application in, 5 689... 

Hammer KA, Carson CF, Riley TV. (2004) Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae. J Antimicrob Chemother 53 1081-1085. 

Anti-yeast activity. The essential oil, on agar plate, was inactive on Saccharomyces cervisiae ° . Ethanol (95%) extract of the dried rhizome, in broth culture at a concentration of 10%, was inactive on Candida albicans, Candida glabrata, and Candida tropicalis ° °. Ethanol (90%) extract of the dried rhizome, on agar plate at a concentration of 500 mg/disc, was inactive on Candida albicans ° ... 

Yeasts (Candida glabrata and Schizosaceharomyces pombe) Size-quantized CdS is biosynthesized... 

Mehra, R.K., Garey, J.R., Butt, T.R., Gray, W.R. Winge, D.R. (1989). Candida glabrata metallothioneins, cloning and sequence of the genes and characterization of proteins. Journal of Biological Chemistry 264, 19747-53. 

Candida glabrata (yeast) Schizosaccharomyces pombe (yeast)... 

Fig. 10. Sequence of the Cu regulatory domain (CuRD) of Ace 1 from Saccharomyces cerevisiae. Eight cysteinyl residues form the CuRD. A consensus sequence is derived from orthologues from Candida glabrata (Amt 1) and Yarrowia lipolytica (Crfl). The presence of a large variable segment in the middle of the CuRD suggests that the CuRD consists of two lobes with four Cys residues each. The tetracopper cluster is likely buried between these two-lobe polypeptides.

Cormak BP, Ghori N, Falkow S An adhesin of the yeast pathogen Candida glabrata mediating adherence to human epithelial cells. Science 1999 285 578-582. 

Nishida T, Mayumi H, Kawachi Y, Tokunaga S, Murayama A, Yasui H, Tokunaga K The efficacy of fluconazole in treating prosthetic valve endocarditis caused by Candida glabrata Report of a case. Surg Today Tokyo 1994 24 651-654. 

Hickley WF, Sommerville LH, Schoen FJ Disseminated Candida glabrata Report of a unique severe infection and a literature review. Am J Clin Pathol 1983 80 724-727. 

Hoppe JE, Klingebiel T, Niethammer D Selection of Candida glabrata in pediatric bone marrow transplant recipients receiving fluconazole. Pediatr Hematol Oncol 1994 11 207-210. 

The best studied Cd-y-EC peptide complexes containing acid labile sulfide as an additional component were isolated from yeasts S. pombe and Candida glabrata where y-EC peptides were shown to coat the CdS particles. Ratios of S Cd in these heterogenous complexes vary from 0.1 to 0.6. This diversity is paralleled by a nondiscrete variation in apparent molecular mass between about 3500-6400 Da, determined by gel exclusion chromatography. These complexes exhibit a red-shifted absorption profile with a new band in the near-UV region (between 270-320nm) when compared to the... 

An interesting development in this field is the recent report by Dameron et al. (88) of the biosynthesis of quantum-sized CdS crystals in the yeast cells Candida glabrata and Schizo saccharomyces pombe. Exposed to Cd ions these cells synthesize certain peptides with an enhanced sulfide production. Small CdS crystals are formed inside the cells. These crystallize in the rock salt structure (and not in the thermodynamically stable hexagonal configuration). The organism controls particle nucleation and growth, so that uniformly sized CdS particles of about 20 A are formed. They show pronounced quantum-size effects. This is the first example of the biosynthesis of quantum-sized semiconductor crystallites. It constitutes a metabolic route for the detoxification of Cd " -infected living cells (see also 89). 

Nair, S., Kumar, K.S., Sachan, P., Corpuz, M. Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis. J. Clin. Gastroenterol. 2001 32 362-364... 

A 68-year-old woman with Candida glabrata isolated from a presacral abscess developed torsade de pointes after 8 days treatment with oral fluconazole 150 mg/day (32). She had no other risk factors for torsade de pointes, including coronary artery disease, cardiomyopathy, congestive heart failure, or electroljde abnormalities. The dysrhythmia resolved when fluconazole was withdrawn, but she continued to have ventricular extra beats and non-sustained ventricular tachycardia for 6 days. 

Opportunistic Candidosis (superficial/systemic) Candida albicans Candida glabrata Candida parapsilosis... 

D.J., Ward, D.J., Marsden, K., and Bennett, J.E. (1998) Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDHl, in Candida glabrata. Antimicrobial Agents and Chemotherapy, 42, 1695-1701. 

Tsai, H.F., Krol, A.A., Sarti, K.E.. and Bennett, J.E. (2006) Candida glabrata PDRl, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants. Antimicrobial Agents and Chemotherapy, 50. 1384—1392. 

Brun, S., Aubry, C., Hma. O., Filmon, R., Berges, T., Chabasse, D.. and Bouchara, J.P. (2003) Relationships between respiration and susceptibility to azole antifungals in Candida glabrata. Antimicrobial Agents and Chemotherapy, 47, 847-853. 

Holmes, A.R., Monk, B.C., Cannon, R.D., and Uehara, Y. (2002) Candida glabrata ATP-binding cassette transporters Cdrlp and Pdhlp expressed in a Saccharomyces cerevisiae strain deficient in membrane transporters show phosphorylation-dependent pumping properties. 

Metzler, L., Takano, Y, Chihana, H., and Niimi, M. (2007) The Candida glabrata putative sterol transporter gene CgAUSl protects cells against azoles in the presence of serum. The Journal of Antimicrobial Chemotherapy, 60, 1264-1272. 

Bodey GP, Mardani M, Hanna HA, et al. The epidemiology of Candida glabrata and Candida albicans fungemia in immunocompromised patients with cancer. Am J Med 2002 112 380-385. 

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