Anti-yeast activity

DIAZOLIDINYL UREA Water soluble Weak anti-yeast activity... 

Anti-yeast activity. Ethanol (100%) extract of the seed, on agar plate at a concentration of 18.7 mg/mL, was active on Candida albicans. Water extract of the seed, on agar plate was inactive on Candida albicans °b Arrhythmogenic effect. Hot water extract of the dried seed, administered orally to adults with cardiac abnormalities at a dose of 200 mg/person, produced equivocal effect . 

Anti-yeast activity. Ethanol (50%) extract of the dried root, on agar plate at a concentration of 500 mg/mL, was inactive on Candida albicans and Saccharomyces pasta-rianus°. ... 

Anti-yeast activity. The essential oil, on agar plate, was inactive on Saccharomyces cervisiae ° . Ethanol (95%) extract of the dried rhizome, in broth culture at a concentration of 10%, was inactive on Candida albicans, Candida glabrata, and Candida tropicalis ° °. Ethanol (90%) extract of the dried rhizome, on agar plate at a concentration of 500 mg/disc, was inactive on Candida albicans ° ... 

Nonproteinohenic proline derivatives 9 and 10 have been detected in the cyclic peptide scytonemin A, a metabolite of the cultured cyanophyte Scytonema sp. which possesses potent calcium antagonistic properties. (2S,47 )-4-Hydroxyproline (8) and (25, 35, 45 )-3-hydroxy-4-methylproline (11) were found in echinocandin B, C and D, which were isolated from a strain of Aspergillus ruglosus and Aspergillus nidulans and characterized by their high antifungal and anti-yeast activities. 

Tran, D.Q., Ide, C.R, and McLachlan, J.A. et al. (1996). The anti-estrogenic activity of selected polynuclear aromatic hydrocarbons in yeast expressing human estrogen receptor. Biochemical and Biophysical Research Communications 229, 102-108. 

Bahrami K, Khodaei MM, Farrokhi A (2009) Highly efficient solvent-free synthesis of dihydropyrimidinones catalyzed by zinc oxide. Synth Commun 39 1801-1808 74. Gross GA, Wurziger H, Schober A (2006) Solid-phase synthesis of 4,6-diaryl-3,4-dihydro-pyrimidine-2(lH)-one-5-carboxylic acid amide derivatives a Biginelli three-component-condensation protocol based on immobilized beta-ketoamides. J Comb Chem 8 153-155 Desai B, Dallinger D, Kappe CO (2006) Microwave-assisted solution phase synthesis of dihydropyrimidine C5 amides and esters. Tetrahedron 62 4651 664 Kumar A, Maurya RA (2007) An efficient bakers yeast catalyzed synthesis of 3,4-dihydro-pyrimidin-2-(lH)-ones. Tetrahedron Lett 48 4569-4571 77. Zalavadiya P, Tala S, Akbari J, Joshi H (2009) Multi-component synthesis of dihydropyrimidines by iodine catalyst at ambient temperature and in-vitro anti mycobacterial activity. Arch Pharm 342 469-475... 

The Indian tree Nothapodytes foetida (syn. Mappia foetida) is an important source of camptothecin, the DNA topoisomerase I inhibitor possessing anti-cancer and anti-HIV activity of significant therapeutic importance. One of the minor components of the plant has been identified as 9-methoxy-20-(S)-mappicine, a tetracyclic derivative of the pentacyclic camptothecin. When the latter compound was treated for a short-time (7 min) with microwave irradiation, it was converted into 9-methoxymappicine ketone with an exceptionally high yield of 95%. This ketone was then easily transformed by baker s yeast into the target compound 9-methoxy-20-(S)-mappicine as illustrated in Fig. 15 [91]. 

HIV proteinase inhibitors may display a specific anti-Sap activity leading to a reduced number of C. albicans yeasts on epithelial cells. Therefore, development of specific aspartic proteinase inhibitors might be useful in the treatment of mucosal candidiasis. The precise function of Candida Saps in the adherence process is not known, but two hypotheses can be advanced (1) the Candida Saps could act as ligands to surface proteins of the specific host cells, which do... 

Several substituted dihydroxybenzoic acids have been examined by the yeast oedema and granuloma pellet test in rats , and anti-inflammatory activity appears to be restricted to the substituted 2,6-dihydroxy compounds. The presence of a halogen at Cg and Cj produces activity which is further increased when a methyl or benzyl group is also present at G4. 4-Benzyl-2,6-dihydroxybenzoic acid is also active, despite the absence of halogen at Cg or C5. The most potent compound of all is 3,5-dichloro-2,6-dihydroxy-4-methylbenzoic acid XIII). Whenever anti-inflammatory activity has been... 

Since the drug was comprehensively reviewed by Heuper in 1948 , only recent studies dealing with certain aspects of its anti-inflammatory activity will be discussed. In subcutaneous doses of 500 mg/kg it reduces formalin oedema of the rat-foot and, in oral doses of 375 mg/kg, it inhibits yeast and formalin but not 5-hydroxytryptamine oedema of the mouse-foot i . When given in doses of 75 and 200 mg/kg before, and 8 hours after, tuberculin, it... 

The Buchwald-Hartwig reaction has been widely used in organic chemistry for the palladium-catalyzed cross-coupling of amines with aryl halides. In particular, it has been used in conjunction with benzothiophenes for arylamination of the thiophene. The final diarylamine product below demonstrated anti-fungal activity against dermatophytes, yeasts, and the Aspergillus species. ... 

This material was also detectable in crude cholesterol from animals. Later it was found, that irradiation of ergosterol, a steroid from baker s yeast, led to a mixture of products with extraordinarily high anti-rachitic activity. At the end of the 1920s, Otto Rosenheim, Thomas Arthur Webster and Adolf Windaus succeeded, independently of each other, in isolating first the unpurified Vitamin D (Vitamin Dj, a mixture of ergocalciferol and lumisterolj) and later the pure crystalline Vitamin D (Vitamin D2, ergocalciferol). The structure determination followed by classical chemical degradation. 

As mentioned above, ketoprofen is widely used in clinical practice as a nonsteroidal anti-inflammatory drug, like the other 2-arylpropionic acids such as naproxen and ibuprofen. The anti-inflammatory activity of ketoprofen was previously believed to reside in its (S)-enantiomer. However, research has indicated that the (f )-enantiomer of ketoprofen was able to prevent periodontal disease and was thus of pharmacological value as a toothpaste additive. It has also been discovered that (i )-ketoprofen has several previously unappreciated advantages as an analgesic and antipyretic. Another yeast strain, Citeromyces matriemis CGMCC 0573, was therefore isolated for the enantioselective hydrolysis of (i )-ketoprofen ethyl ester. ... 

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