Peritonitis fungal

Reductions in renal and hepatic function do not alter plasma drug concentrations, and ketoconazole is not removed by hemodialysis or peritoneal dialysis. Penetration into cerebrospinal fluid is negligible, so that ketoconazole is ineffective in the treatment of fungal meningitis. Since only small amounts of active drug appear in the urine, ketoconazole is not effective in the treatment of Candida cystitis. 

Nair, S., Kumar, K.S., Sachan, P., Corpuz, M. Spontaneous fungal peritonitis (Candida glabrata) in a patient with cirrhosis. J. Clin. Gastroenterol. 2001 32 362-364... 

Cleophas, V., George, V., Mathew, M., Samal, S.C., Chandry, G.M. Spontaneous fungal peritonitis in patients with hepatitis B virus-related liver disease. J. Clin. Gastroenterol. 2000 31 77-79... 

Nakamura M, Weil WB Jr, Kaufman DB. Fatal fungal peritonitis in an adolescent on continuous ambulatory peritoneal dialysis association with deferoxamine. Pediatr Nephrol 1989 3(l) 80-2. 

Goldie SJ, Kiernan-Tridle L, Torres C, et al. Fungal peritonitis in a large chronic peritoneal dialysis population a report of 55 episodes. Am J Kidney Dis 1996 28 86-91. 

Williams PF, Moncrieff N, Marriott J. No benefit in using nystatin prophylaxis against fungal peritonitis in peritoneal dialysis patients. Perit Dial Int 2000 20 352-353. 

Caspofungin is indicated in the treatment of invasive aspergillosis in patients refractory to, or intolerant of, other antifungal therapies empirical treatment for presumed fungal infections in febrile, neutropenic patients treatment of esophageal candidiasis treatment of candidemia and the following Candida infections intra-abdominal abscesses, peritonitis, and pleural space infections. 

Mixed infections Multiple organisms may be involved in some infections. For example, peritoneal infections may be caused by several pathogens (eg, anaerobes and coliforms) a combination of drugs may be required to achieve coverage. Skin infections are often due to mixed bacterial, fungal, or viral pathogens. 

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