Pleiotropic drug resistance

WOLFGER, H., MamNUN, Y. M., Kuchler, K., Fungal ABC proteins pleiotropic drug resistance, stress response and cellular detoxification, Res. Microbiol. 2001, 152, 375-389. 

Membrane Transporters in Pleiotropic Drug Resistance and Stress Response in Yeast and Fungal Pathogens... 

Abbreviations NBD, nucleotide binding domain TMS, transmembrane-spanning segment NTE, N-terminal extension PDR, pleiotropic drug resistance PM, plasma membrane V, vacuole M, mitochondrion P, peroxisome C, cytoplasm LCFA, long chain fatty acid EF, elongation factor. 

Abbreviations TF, transcription factor PDR, pleiotropic drug resistance bZip, basic leucine zipper. 

Kolaczkowski, M., Kolaczowska, A., Luczynski, J., Witek, S., and Goffeau, A. (1998) In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network. Microbial Drug Resistance, 4, 143-158. 

Schuller. C.. Mamnun, Y.M., Wolfger, H., Rockwell. N.. Thorner, J., and Kuchler, K. (2007) Membrane-active compounds activate the transcription factors Pdrl and Pdr3 connecting pleiotropic drug resistance and membrane lipid homeostasis in Saccharomyces cerevisiae. Molecular Biology of the Cell, 18, 4932-4944. 

Nourani, A., Papajova, D., Delahodde, A., Jacq, C., and Subik, J. (1997) Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a... 

Mamnun, Y.M.. Pandjaitan, R., Mahe, Y., Delahodde, A., and Kuchler, K. (2002) The yeast zinc finger regulators Pdrlp and Pdr3p con h oi pleiotropic drug resistance (PDR) as homo- and heterodimers in vivo. Molecular Microbiology, 46, 1429-1440. 

Hallstrdm, T.C. and Moye-Rowley, W.S. (2000) Multiple signals from dysfunctional mitochondria activate the pleiotropic drug resistance pathway in Saccharomyces cerevisiae. The Journal of Biological Chemistry, 275. 37347-37356. 

Talibi, D. and Raymond, M. (1999) Isolation of a putative Candida albicans transcriptional regulator involved in pleiotropic drug resistance by functional complementation of a pdrl pdr3 mutation in Saccharomyces cerevisiae. Journal of Bacteriology, 181, 231—240. 

Tsai, H.F., Krol, A.A., Sarti, K.E.. and Bennett, J.E. (2006) Candida glabrata PDRl, a transcriptional regulator of a pleiotropic drug resistance network, mediates azole resistance in clinical isolates and petite mutants. Antimicrobial Agents and Chemotherapy, 50. 1384—1392. 

ABC family lipid efflux transporters have also been identified in yeast, and gene products associated with yeast oligomycin resistance, Yorlp, and pleiotropic drug resistance, Pdr5p, have been shown to facilitate the removal of NBD-PE from cells (A. Decottignies,... 

Some tumors become resistant to several classes of antitumor agents, even if they have never been exposed to some of these agents. This is called multidrug (or pleiotropic drug) resistance. Drugs to which these cells become resistant include antibiotics, colchicine, the vinca alkaloids (vincristine vinblastine) and epidophyllotoxins (VP-16). These agents do not share a common mechanism of action. 

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