Cancer of the respiratory tract

Toxicology. Sulfuric acid is a severe irritant of the respiratory tract, eyes, and skin contact with the teeth causes dental erosion cancer of the respiratory tract has been associated with chronic exposure. 

While chromium metal or trivalent chromium is not very toxic, hexavalent chromium (Cr +) is carcinogenic and moderately toxic. Cr + is corrosive to skin and causes denaturation and precipitation of tissue proteins. Inhalation of Cr6+ dust or mist can cause perforation of the nasal septum, lung irritation, and congestion of the respiratory passsages. Chronic exposure may produce cancer of the respiratory tract. 

Muir DCF, Jadon N, Julian JA, et al. 1994. Cancer of the respiratory tract in nickel sinter plant workers effect of removal from sinter plant exposure. Occup Environ Med 51(1) 19-22. 

Easton, D. F., Peto, J., Doll, R. (1988). Cancers of the respiratory tract in mustard gas workers. British Journal of Industrial Medicine, 45, 653-659. 

Andjelkovich DA, Janszen DB, Conolly RB, et al. 1995b. Fonnaldehyde exposure not associated with cancer of the respiratory tract in iron foundry workers A synopsis of CUT epidemiologic findings. CUT Act 15 1-9. 

Radioactive Strontium. The only respiratory effects reported for the study in which beagle dogs were exposed to soluble aerosols of 90SrCl2 (Boecker et al. 1969 Gillett et al. 1987b) were late primary cancers of the respiratory tract or tumors metastasizing to the lung. These effects are discussed in Section 3.2.1.7 Cancer. 

Minoue, R. and Shizushiri, S., Occupationally-related lung cancer—Cancer of the respiratory tract as sequentia from poison gas plants, Jpn. J. Thorac. Dis., 18, 845, 1980. 

The numerous publications during the past two decades on the identification, quantitation, and bioassay of NNAs, particularly those found in tobacco-related entities [tobacco, mainstream smoke (MSS), sidestream cigarette smoke (SSS), and environmental tobacco smoke (ETS)] raise the question as to why this class of tobacco/tobacco smoke components has received such emphasis. Since the early 1950s, several classes of compounds in tobacco smoke have been proposed as prime contributors to cancer of the respiratory tract in smokers. The events that triggered detailed examination of the composition of cigarette MSS included ... 

Nesnow S, Triplett LL, Slaga TJ, et al. 1985. Carcinogenesis A comprehensive survey. Volume 8. In Mass MJ, Kaufman DG, Siegfried JM, eds. Cancer of the respiratory tract Predisposing factors. New York, NY Raven Press, 257-277. 

Other cancers of the respiratory tract are documented also, e.g., cancer of the nasal cavity, pleural mesothelioma with high incidences in painters and paper-hangers and cancers of the larynx. ... 

BuP and other PAHs produce liver and lung tumors within half a year following intraperitoneal and subcutaneous injection to new born animals. Skin tumors after dermal application of PAHs to mice provides a background for the initiation/promotion theory in chemical carcinogenesis. BuP is the only PAH that has been tested following inhalation. Long-term inhalation of 10 mg BuP per m resulted in cancer of the respiratory tract in 35% of golden hamsters. 

Subcutaneous injections of cadmium salts in rats induce sarcoma at the site of injection and may also give rise to interstitial tumors in the testis. " In human beings, cadmium has been suggested as an etiologic factor in the development of prostatic carcinoma" " " and cancer of the respiratory tract. "... 

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