Cancer Lymphosarcoma

An epidemiological study of workers potentially exposed to MDA (and numerous other agents) in the helicopter parts manufacturing industry showed limited evidence of an association between MDA and bladder cancer, colon cancer, lymphosarcoma, and reticulosar-coma." A follow-up of 10 workers who had significant exposure to MDA between 1967 and 1976 revealed one case of a pathologically... 

Lymphosarcoma, severe psoriasis, cancer of the head, neck, breast, lung, rheumatoid arthritis (RA) Alpha-interferon-refractory hairy cell leukemia... 

Ellens, H., Morselt, H. W. M., Dontje, B. H. J., Kalicharan, D., Hulstaert, C. E., and Scherphof, G. L. (1983). Effects of liposome dose and the presence of lymphosarcoma cells on blood clearance and tissue distribution of large unilamellar liposomes in mice, Cancer Res.. 43. 2927-2934. 

In humans, cases of hepatomas have appeared years after acute exposure to carbon tetrachloride, however, none of the cases could establish a causal link between the exposure and development of neoplasms." Epidemiological studies have also given inconclusive results. A cancer mortality study of a population of rubber workers reported a significantly elevated odds ratio relating carbon tetrachloride with lymphatic leukemia, and lymphosarcoma and reticulum cell carcinoma." A recent retrospective cohort mortality study of aircraft maintenance workers found an increased risk of... 

Repeated subcutaneous or intraperitoneal injection of manganese dichloride caused increased incidences of lymphosarcomas in mice. Chronic oral exposure of rats to manganese sulfate led to a slight increase in pancreatic tumors that was not dose responsive." There is no information relating manganese exposure to cancer occurrence in humans." Genotoxic assays have yielded mixed results."... 

It has been postulated that wood dust carcinoma results from a multistep process Exposure causes loss of cilia and hyperplasia of the goblet cells and initiation of cuboidal cell metaplasia, followed (after a quiescent period) by squamous cell metaplasia. Decades later, cellular aplasia leads to nasal adenocarcinoma. The time between first occupational exposure to wood dust and the development of nasal cavity adenocarcinoma averages 40 years. Other cancers, including lung cancer, Hodgkin disease, multiple myeloma, stomach cancer, and colorectal cancer and lymphosarcoma, have been mentioned in relation to wood... 

A small cohort study of 1,3-butadiene production workers showed a significant excess of lymphosarcoma and reticulosarcoma, based on four cases. There was also an excess of stomach cancer, although represented by only five cases. Two leukaemia cases were found this was slightly more than expected. 

A nested case-control study within a cohort of rubber workers in the United States was performed to examine the relationship between exposure to solvents and the risk of cancer (Checkoway et al., 1984 Wilcosky et al., 1984). The cohort consisted of 6678 male rubber workers who either were active or retired between 1964 and 1973. The cases comprised all persons with fatal stomach cancer (n = 30), respiratory system cancer (z7 = 101), prostate cancer ( = 33), lymphosarcoma (n = 9) or lymphocytic leukaemia (z7 = 10). These sites were chosen because they were those at which cancers had been found to be in excess in an earlier cohort analysis (McMichael et al., 1976). The controls were a 20% age-stratified random sample of the cohort (z = 1350). Exposure was classified from a detailed work history and production records. An association was observed between exposure for one year or more to carbon tetrachloride and lymphocytic leukaemia (odds ratio (OR), 15.3 / < 0.0001, based on eight exposed cases) and lymphosarcoma (OR, 4.2 p < 0.05, based on six exposed cases) after adjusting for year of birth. The relative risk associated with 24 solvents was examined and levels of exposure were not reported. [The Working Group noted that overlapping exposures limit the ability to draw conclusions regarding carbon tetrachloride.]... 

In a case-control study within a cohort of 6678 rubber workers in the United States (lARC, 1987) (Wilcosky et al., 1984), one of the substances assessed was xylene, which was analysed as a potential risk factor in relation to each of five cancer types. There were somewhat increased odds ratios (OR) for prostate cancer (OR, 1.5 n = 8), lymphosarcoma (OR, 3.7 n = 4 p < 0.05) and lymphatic leukaemia (OR, 3.3 n = 4). [The Working Group noted that workers were typically exposed to multiple exposures.]... 

Cyclophosphamide (Cytoxan and Endoxan) is used in the treatment of Hodgkin s disease, lymphosarcoma, and other lymphomas. It is employed as a secondary drug in patients with acute leukemia and in combination with doxorubicin in women with breast cancer. A drug combination effective in the treatment of breast cancer is cyclophosphamide, methotrexate, fluorouracil, and prednisone (CMFP). Cyclophosphamide is also an immunosuppressive agent. The toxicity of cyclophosphamide causes alopecia, bone marrow depression, nausea and vomiting, and hemorrhagic cystitis. 

Brunson, K. W. and Nicolson, G. L. (1978). Selection and biologic properties of malignant variants of a murine lymphosarcoma. J. Natl. Cancer Inst. 61,1499-1503. 

Chlorambucil is an alkylating agent that retards or stops growth of cancer cells. It is used to treat chronic lymphocytic leukemia, malignant lymphomas such as lymphosarcoma, giant follicular lymphoma, ovarian cancer, and Hodgkin s disease. 

Statistically non-significant SMRs were obtained for mortalities from the following hematologic-related cancers combined neoplasms of the lymphatic and hematopoietic tissues, lymphosarcoma and reticulosarcoma, Hodgkins disease, leukemia and aleukemia, other lymphatic neoplasms. 

Abelson HT, Rabstein LS (1970) Lymphosarcoma virus-induced thymic-independent disease in mice. Cancer Res 30 2213-2222... 

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