Quassinoids from Brucea javanica

Quassinoids —The antileukaemic activity of some quassinoids has revived interest in this group. Three new biologically active compounds have been isolated. Quassimarin (118) occurs in Quassia amara with the inactive simalikalactone D (129) 86 Bruceoside A, from Brucea javanica, is the glucoside (120). The third... 

Fukamiya N, Okano M, Miyamoto M (1992) Antitumor Agents, 127. Bruceoside C, a New Cytotoxic Quassinoid Glucoside and Related Compounds from Brucea javanica. J Nat Prod 55 468... 

Eighteen quassinoids glycosides and nine known quassinoids isolated from Brucea javanica, Brucea cmtidysenterica and Ailanthus altissima were tested for inhibitory activity against HIV replication in H9 lymphocytic cells [103],... 

Forty-five quassinoids isolated from the three Simaroubaceous plants, Brucea javanica, Brucea antidysenterica and Picrasma ailanthoides, and fourteen isolated from Ailanthus altissima were tested for Okano et al. [106-108] for their inhibitory activities using a short-term in vitro assay of the EBV-EA activation induced by TP A in Raji cells. 

Several quassinoids are known to have antileukemic activity (Blasko and Cordell, 1988 Cordell, 1978 Polonsky, 1983). Only compounds with a C20 skeleton have antileukemic activity. Quassimarin (51) from Quassia amara and bruceoside A (52) from Brucea javanica and a series of other quassinoids from Brucea antidysenterica (all Simarou-baceae) (Fig. 25.12) are active in this regard. Bruceantin (53) has a high degree of antitumor activity in P-388, LE, LL and B16 tissue culture systems (Cordell, 1978). Six quassinoids from Simaba multiflora and Soulamea soulameoides were shown to be active against several mmor systems (Klocke et al., 1985). 

Ohnishi S, Fukamiya N, Okano MJ (1995) Bmceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica. J Nat Prod 58 1032—1038. 

Yan XH, Chen J, Di Y-T, Fang X, Dong J-H, Sang P, Wang Y-H, He H-P, Zhang Z-K, Hao X-J (2010) Anti-Tobacco Mosaic Virus (TMV) Quassinoids from Brucea javanica (L.) Merr. J Agric Food Chem 58 1572-1577... 

Bawm S, Matsuura H, EUdiateeb A, Nabeta K, Subeki, Oku NNY, Katakura K (2008) In vitro antitrypanosomal activities of quassinoid compounds from the fruits of a medicinal plant, Brucea javanica. Vet Parasitol 158 288-294... 

Elkhateeb A, Yamasaki M, Maede Y, Katakura K, Nabeta K, Matsuura H (2008) Antibabesial quassinoids from the fruits of Brucea Javanica. Nat Prod Comm 3 145 Almeida MMB, Arriaga AMC, dos Santos AKL, Lemos TLG, Braz-Filho R, Vieira DC (2007) Occurrence and biological activity of quassinoids in the last decade. Quim Nova... 

---