Antileukemic principle

These reactions have been applied to synthetic studies on biologically active compounds such as l/ -methylcarbapenem (87), the antileukemic principle, pareitropone (88), and the potentially antiinflammatory marine alkaloid, halichlorine (89). 

Lee KH, Hayashi N, Okano M, Nozaki H, Juichi M (1984) Antitumor agents, 65. Brusatol and Cleomiscosin A, Antileukemic Principles from Brucea javanica. J Nat Prod 47 550... 

KH Lee, K Tagahara, H Suzuki, RY Wu, M Haruna, IH Hall, HC Huang. Antitumor agents. 49. Tricin, Kaempherol-3-O-P-D-glucopyranoside and (-l-)-nortrachelogenin, antileukemic principles from Wikstroemia indica. J Nat Prod 44 530-535, 1981. 

Kupchan SM, Karim A. Tumor inhibitors in aloe emodin antileukemic principle isolated from Rhamnus frangula L. Lloydia 1976 39 223-4. 

Piceatannol, an antileukemic principle known to inhibit proteine-tyrosine kinase (PTK) was chosen as a lead compound for SAR analysis. The fully symmetrical 5-hydroxy isomer was found to be four times more potent than piceatannol. When compared with the reference monomer A46, the fcw-tyrphostin was found to be 150 times more potent in protein tyrosine kinase... 

The first benzenoid ansa macrolide maytansine (73) was isolated from the bark of the Celastraceae plant Maytenus ovatus as an antileukemic principle [119, 120]. 

Al-Yahya MA, Khafagy S, Shihata A, Kozlowski JF et al. 1984 Phytochemical and biological screening of Saudi medicinal plants. Part 6. Isolation of 2-Alpha-hydroxy-alantolactone, the antileukemic principle of Francoeuria crispa. J Nat Prod 47 1013-1017... 

Qian XL, Yao SH 1982 Studies on the antileukemic principle of Maytenus guangxiensis Cheng Et Sha. II. In Wang Y (ed) Chemistry of Natural Products-Proc Sino-American Chem Nat Prod. Science Press, Beijing, p. 263-264... 

Konoshima, T. and Lee, K.-H. (1986) Antitumor agents. Cicutoxin, an antileukemic principle from Cicuta maculata, and the cytotoxicity of the related derivatives. /. Nat. Prod., 49,1117-1121. Kris-Etherton, P.M., Etherton, T.D., Carlson, J. et al. (2002) Recent discoveries in inclusive food-based approaches and dietary patterns for reduction in risk for cardiovascular disease. Curr. Opin. Lipid, 13, 397-407. 

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