Brucea antidysenterica

I-Hydroxy-ll-methoxycanthin-6-one C,5H,oN203 — Brucea antidysenterica Simaroubaceae 26,47... 

I-Methoxycanthin-6-one (11) has been isolated from the root bark (79,22), wood 18), stem (25), and leaves (24) of A. altissima, its cell culture 14-16), the root bark of A. excelsa 25), the ground wood of Brucea antidysenterica 26), the root of Hannona klaineana (27), and Soulamea pancheri 28). Based on results of comparisons between... 

Another example of an old drug in the process of revival is bruceantin (52), which was first isolated from Brucea antidysenterica], F. Milk, a tree used in Ethiopia for the treatment of cancer . As often happens, activity observed in animal models bearing a range of tumors was not matched by any objective responses in clinical trials, resulting in termination of further development. " ... 

The root bark of Brucea antidysenterica Mill., used in folk... 

Forty-five quassinoids isolated from the three Simaroubaceous plants, Brucea javanica, Brucea antidysenterica and Picrasma ailanthoides, and fourteen isolated from Ailanthus altissima were tested for Okano et al. [106-108] for their inhibitory activities using a short-term in vitro assay of the EBV-EA activation induced by TP A in Raji cells. 

The most seven potent compounds include isobrucein-B (235), bruceanol A (64), G (70), D (67), B (65), E (68), and bruceantin (234), which were all isolated from Brucea antidysenterica. All these compounds are aglycones with C=0 and OH groups in ring A, a -... 

C28H36O11, Mr 548.59, cryst., mp. 225-226°C, [a] -27.7° (pyridine). Quassinoid with antileukemic activity from the tree Brucea antidysenterica (Simarou-baceae). lDjq (mouse i.v.) male 1.95 mg/kg, female 2.58 mg/kg. 

Several quassinoids are known to have antileukemic activity (Blasko and Cordell, 1988 Cordell, 1978 Polonsky, 1983). Only compounds with a C20 skeleton have antileukemic activity. Quassimarin (51) from Quassia amara and bruceoside A (52) from Brucea javanica and a series of other quassinoids from Brucea antidysenterica (all Simarou-baceae) (Fig. 25.12) are active in this regard. Bruceantin (53) has a high degree of antitumor activity in P-388, LE, LL and B16 tissue culture systems (Cordell, 1978). Six quassinoids from Simaba multiflora and Soulamea soulameoides were shown to be active against several mmor systems (Klocke et al., 1985). 

Imamura K, Fukamiya N, Nakamura M, Okano M, Tagahara K, Lee KH (1995) Bruceanols G and H, cytotoxic quassinoids from Brucea antidysenterica. J Nat Prod 58 1915-1919... 

Species belonging to the Simaroubaceae family are widely referenced in the pharmacopoeias of different medical systems around the world, whether they be of contemporary or ancient use, transmitted orally, or from written sources. For example, Ailanthus altissima, the area of natural distribution of which extends from Manchuria to Malaysia, is one of the most cited species in ancient Chinese medical treatise for a wide range of indications. One of the oldest recipes for this species has been recorded in a book in China dating back to 732 AD for the treatment of mental illness [110]. Its bark is stiU registered in actual Chinese and Asian pharmacopoeias, and it is traded across China. The same applies to Brucea javanica fruits in Southeast Asia and to Ailanthus excelsa Roxb. bark, mentioned in ancient and contemporary ayurvedic medicine books [111]. The use of Brucea antidysenterica bark has also been documented since the sixteenth century in ancient Arabic medical pharmacopoeias [112]. 

Ailanthus altissima, Brucea antidysenterica, Picrasma excelsa. Quassia africana. Quassia undulata, Simaba cedron, and Simarouba amara are also used as anthelmintics. 

Ailanthus altissima, A. excelsa, A. integrifolia subsp. calcynia (Pierre) Noot., Brucea antidysenterica, B. javanica, Castela emoryi (A.Gray) Moran Felger,... 

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