Quassinoid glycosides

Quassinoid glycosides named bruceantinoside (72) and the new bruceanic acids B (73), C (74), and D (75) were isolated from wood Brucea antitfysenterica [39-40], Bruceanic acid D (75) was cytotoxic against P-388 (ED50 0.77 pg/mL). 

Three quassinoids named yadanziolides A (90), B (91), and C (92), and four quassinoids glycosides named yadanziosides F (93), I (94), J (95), and L (96) were isolated from water-soluble fraction methanol extract of seeds of Bruceci javanica Merr., and their structures were determined by spectral and chemical means [44]. 

Chaparramarin (113) exhibited moderate insect inhibitory activity against the lepidopteran pest insect, Heliothis virescem (tobacco budworm) [51]. Three quassinoids glycosides, casteloside A (115), casteloside B (116), and casteloside C (117) were also from the bark of Castela tortuosa [53-54],... 

Hatmoa klaineana Pkre et Engler decoctions are used in African traditional medicine against fever and intestinal diseases [61]. Two quassinoids glycosides 15-0-f3-D-glycopyranosyl-21 -... 

Quassinoids of the Japanese Picrasma ailanthoides Planchon (= P. quassioides Bennett) have been investigated in detail and more than twenty quassinoids have been obtained until 1984. However, very few reports for quassinoid glycosides have been found [63]. Eight quassinoids glycosides, picrasinoside A (141), B (142), C (143), D (144), E (145), F (146), G (147), H (148), and quassinoids hemiacetals, picrasinol A (149), B (150), C (151), and D (152) were isolated from Picrasma ailanthoides the last two decades [63-66]. 

Quassia amara Wood is still widely used in traditional medicine and some quassinoids and quassinoid glycosides isolated from Quassia have received renewed attention due to their biological activity as potential antitumor agents [78]. 

Eighteen quassinoids glycosides and nine known quassinoids isolated from Brucea javanica, Brucea cmtidysenterica and Ailanthus altissima were tested for inhibitory activity against HIV replication in H9 lymphocytic cells [103],... 

ANTI-HIV ACTIVITY OF NATURAL QUASSINOID GLYCOSIDES AND THEIR AGLYCONES... 

Lee KH, frnakura Y, Huang HC (1977) Bruceoside-A, a novel antileukaemic quassinoid glycoside frtnn Brucea javanica. J Chem Soc Chem Commun 2 69... 

Okano and Lee (73) converted the quassinoid glycoside bruceoside-A (64) to bruceantin (53). The methods used involved selective hydrolysis of the ester and glycosyl groups followed by esterification of the hydroxyl at position 15. 

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