Genome-sequencing projects

With the onset of genomic biology, there are now many sequences derived from genome sequencing projects that are too divergent to be considered species variants of known peptidases. Of the 54,124 sequences in the MEROPS database only 18,741 (34.6%) have been assigned to an identifier. 

All predicted protein sequences lacking any significant sequence similarity to characterized proteins are labeled hypothetical proteins. The majority of these cases come from the genome sequencing projects. Example ... 

WORMPEP Caenorhabditis elegans genome sequencing project protein database (WormPep)... 

This chapter anticipates the completion of Arabidopsis thaliana, Drosophila melanogaster, and Homo sapiens genome sequencing projects by reviewing current ideas of the evolution of sequence families. In parallel the related issue of domain homolog detection is discussed in light of continuing efforts to map the complete set of domain families. 

Rat Genome Sequencing Project Gonsortium. 2004. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428 493. 

Excellent source of information regarding various completed/ongoing genome sequencing projects. 

The advent of rapid DNA cloiung and sequencing techniques, and the pubhc availability of nucleotide sequence information from the tikes of ttie tiuman genome sequencing project, various expressed sequence tag (EST) databases, and various... 

Analysis of the data from the I vaginalis genome sequencing project indicates that the mechanisms involved in acquisition of metronidazole resistance by this parasite might be more complex than currently understood. 

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