Resveratrol breast cancer

Levenson AS, Gehm BD, Pearce ST, Horiguchi J, Simons LA, Ward JE 3rd, Jameson JL, Jordan VC. 2003. Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha. Int J Cancer 104 587-596. 

Lu R, Serrero G. 1999. Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells. J. Cell Physiol 179 297-304. 

Nakagawa H, Kiyozuka Y, Uemura Y, Senzaki H, Shikata N, Hioki K, Tsubura A. 2001. Resveratrol inhibits human breast cancer cell growth and may mitigate the effect of linoleic acid, a potent breast cancer cell stimulator. J Cancer Res Clin Oncol... 

Scarlatti F, Sala G, Somenzi G, Signorelli P, Sacchi N, Ghidoni R. 2003. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J 17 2339-2341. 

Azios NG, Dharmawardhane SF. 2005. Resveratrol and estradiol exert disparate effects on cell migration, cell surface actin structures, and focal adhesion assembly in MDA-MB-231 human breast cancer cells. Neoplasia 7 128-140. 

Bove K, Lincoln DW, Tsan MF. 2002. Effect of resveratrol on growth of 4T1 breast cancer cells in vitro and in vivo. Biochem Biophys Res Commun 291 1001-1005. 

Garvin S, Ollinger K, Dabrosin C. 2006. Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo. Cancer Lett 231 113-122. 

Lee JE, Safe S. 2001. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells. Biochem Pharmacol 62 1113-1124. 

Li Y, Liu J, Liu X, Xing K, Wang Y, Li F, Yao L. 2006. Resveratrol-induced cell inhibition of growth and apoptosis in MCF7 human breast cancer cells are associated with modulation of phosphorylated Akt and caspase-9. Appl Biochem Biotechnol 135 181-192. 

Tang FY, Chiang EP, Sun YC. 2008. Resveratrol inhibits heregulin-betal-mediated matrix metalloproteinase-9 expression and cell invasion in human breast cancer cells. J Nutr Biochem 19 287-294. 

Tang HY, Shih A, Cao HJ, Davis FB, Davis PJ, Lin HY. 2006. Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol Cancer Ther 5 2034-2042. 

Wang Y, Lee KW, Chan FL, Chen S, Leung LK. 2006. The red wine polyphenol resveratrol displays bilevel inhibition on aromatase in breast cancer cells. Toxicol Sci 92 71-77. 

Gehm BD, Levenson AS, Liu H, Lee EJ, Amundsen BM, Cushman M, Jordan VC, Jameson JL (2004) Estrogenic effects of resveratrol in breast cancer cells expressing mutant and wild-type estrogen receptors role of AF-1 and AF-2. J Steroid Biochem Mol Biol 88 223-234... 

Moreover, resveratrol, a compound found at high levels in red wine, induces apoptosis via increased generation of de novo-generated ceramide in breast cancer cells in situ (Scarlatti et al., 2003, 2007 Minutolo et al., 2005). 

Minutolo, F., Sala, G., Bagnacani, A., Bertini, S., Carboni, I., Placanica, G., Prota, G., Rapposelli, S., Sacchi, N., Macchia, M., and Ghidoni, R. Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells. J Med Chem, 48, 2005, 6783-6786. 

Resveratrol has been shown to inhibit proliferation, induce differentiation, and enhance the expression of adhesion molecules (GDI la, GDI lb, GDIS, GD54) in a variety of myeloid leukemia cell lines [144]. The inhibitory effect of resveratrol on cell survival and proliferation of human breast cancer cells was shown to be estrogen receptor dependent [145]. Other studies indicated that it was very effective in inhibiting growth of 4T1 breast cancer cells in culture but had little effect on 4T1 tumor cell growth in mice [146]. In stark contrast, resveratrol was tested against mammary tumors induced by 7, 12-dimethylbenz(a)anthracene (DMBA) in rats [147]. In this case, reductions in incidence, multiplicity, and latency period of tumor development were observed. Additional... 

Recently it has been shown that resveratrol induces the cAMP/kinase-A system, which makes it a pro-apoptotic and cell-cycle-repressing agent in breast cancer cells. Having such mechanistic activity would suggest that resveratrol might be an effective agent... 

El-Mowafy, A.M. and AUcjalaf, M., Resveratrol activates adenylcyclase in human breast cancer cells a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis, 24, 869,... 

Chemoprevention is an emerging and promising approaeh to control human cancer. Several natnral products have been proven to have potentials as anticancer agents. Resveratrol is one such compound. Recently, increasing interest has focused on examining the effect of resveratrol in breast cancer prevention and treatment. The present review summarizes the recent studies on the role of resveratrol in cancer prevention and therapy, especially in human breast cancer, that provide new insights into the molecular mechanisms of resveratrol. The estrogenic activity of resveratrol, as well as its in vitro and in vivo antiproliferative and chemoprotective activities, will be discussed here. 

EFFECT OF RESVERATROL ON BREAST CANCER CELL PROLIFERATION IN VITRO... 

In several cancer cell lines, resveratrol is capable of inducing apoptosis. In breast cancer cells, Pozo-Guisado et al. ° showed that resveratrol induced apoptosis in MCF-7 but not in MDA-MB-231 cells. Nevertheless, it inhibited cell proliferation in both cell lines. This result suggests that the mechanisms of antiproliferative effect of resveratrol are both apoptotic and nonapoptotic cell death. 

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