Tumor cells growth

The streptovaricins inhibit the reverse transcriptase of some RNA oncogenic vimses that may be involved in the process of viral transformation (see Antiviral agents). The atropisostreptovaricins again have similar activities to the corresponding natural isomers. The streptovals and streptovarone exhibit gready improved activity against reverse transcriptase relative to the streptovaricins (85), but their in vitro activities were low (86). The damavaricins also inhibit reverse transcriptase (4) as well as tumor cell growth (87). 

Shaw RJ, Cantley LC (2006) Ras, PI(3)K and mTOR signalling controls tumor cell growth. Nature 441 424-430... 

Nasimuzzaman M, Kuroda M, Dohno S, Yamamoto T, Iwatsuki K, Matsuzaki S, Mohammad R, Kumita W, Mizuguchi H, Hayakawa T, Nakamura H, Taguchi T, Wakiguchi H, Imai S (2005) Eradication of Epstein-Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNAl. Mol Ther 11 578-590... 

Mayhew, E., Papahadjopoulos, D., Rustum, Y. M., and Dave, C. (1976). Inhibition of tumor cell growth in vitro and in vivo by ARA-C entrapped within phospholipid vesicles. Cancer Res.. 36. 4406-4411. 

Chernomorsky, S., Segehnan, A., and Poretz, R.D., Effect of dietary chlorophyll derivatives on mutagenesis and tumor cell growth, Teratog. Carcinog. Mutag, 19, 313, 1999. 

Tibaduiza, E.C. et al., Excentric cleavage products of beta-carotene inhibit estrogen receptor positive and negative breast tumor cell growth in vitro and inhibit activator protein-1-mediated transcriptional activation, J. Nutr., 132, 1368, 2002. 

Thus, expression of CXCR4 on tumor cells, which is common to many breast cancers as well as other cancer types, may contribute to malignant behavior in several ways. CXCR4 expression by tumor cells may interact with CXCL12 to facilitate tumor cell growth and escape from oxygen starvation-induced apoptosis and as a mechanism to home (metastasize) to secondary sites. 

Sibert JW, Cory AH, Cory JC (2002) Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth. Chem Commun 2 154—155... 

Radical polymerization of maleic anhydride and fullerene was used to obtain a new material, the photodynamic properties of which have been studied in vitro and in vivo. HeLa and bone tumor cell growth were inhibited by treatment with fullerene and light, so the polymer was tested on mice affected by bone tumor. After injection and irradiation, tumor size and weight were reduced and the mouse survival time was extended (Jiang and Li, 2007). The photodynamic properties of a supramolecular cucurbit[8]uril-fullerene complex have been studied by the same authors (Jiang and Li, 2006) who attributed HeLa cell death mainly to the damage of membrane phosphohpids and proteins. 

S. W. Lee, C. L. Reimer, P. Oh, D. B. Campbell, and J. E. Schnitzer. Tumor cell growth inhibition by caveolin re-expression in human breast cancer cells. Oncogene 16 1391-1397 (1998). 

Sulindac is a racemic sulfoxide. Its deoxygenated metabolite (i.e., a sulfide) induces apoptosis, probably through inhibition of PPAR (Peroxisome Proliferator-Activated Receptor) It is probably the reason why suhndac seems to protect against colorectal cancers. Indeed, sulindac inhibits colorectal tumor cell growth. One other metabolite of sulindac, the sulfone exulind, is an inductor of apoptosis, and is currently in Phase III clinical trials for treatment of tumors (Figure 8.3). 

Blanco-Aparicio, C., Molina, M. A., Femandez-Salas, E., Frazier, M. L., Mas, J. M., Querol, E., Aviles, F. X., de Llorens, R. (1998). Potato carboxypeptidase inhibitor, a T-knot protein, is an epidermal growth factor antagonist that inhibits tumor cell growth. J. Biol. Chem., 273, 12370-12377. 

Total Inhibition of In Vivo Tumor Cell Growth by 2-(3 -Halophenyl)-l,8-Naphthyridin-4-... 

Kamei, H., Kojima, T., Hasegawa, M., Koide, T., Umeda, T., Yukawa, T., and Terabe, K. 1995. Suppression of tumor cell growth by anthocyanins in vitro. Cancer Invest. 13 590-594... 

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